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TDM-guided Crushed Sofosbuvir-velpatasvir Treatment: A case study

Abstract : In this study, the authors report the case of a patient diagnosed with hepatitis C virus who was treated with sofosbuvir-velpatasvir (400/100 mg). As the patient was unable to swallow whole tablets, therapeutic drug monitoring was performed to evaluate the effect of crushing sofosbuvir-velpatasvir tablets on drug absorption and global exposure.
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Submitted on : Wednesday, February 12, 2020 - 2:56:31 PM
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Sébastien Lalanne, Caroline Jezequel, Camille Tron, Marie-Clémence Verdier, Marion Mercerolle, et al.. TDM-guided Crushed Sofosbuvir-velpatasvir Treatment: A case study. Therapeutic Drug Monitoring, Lippincott, Williams & Wilkins, 2020, 42 (2), pp.163-164. ⟨10.1097/FTD.0000000000000718⟩. ⟨hal-02440785⟩

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