, MS International Federation. Atlas of MS, 2015.

S. Foulon, G. Maura, and M. Dalichampt, Prevalence and mortality of patients with multiple sclerosis in France in 2012: a study based on French health insurance data, J Neurol, vol.264, pp.1185-1192, 2017.

P. Tuppin, J. Rudant, and P. Constantinou, Value of a national administrative database to guide public decisions: from the syst eme national d'information interr egimes de l'Assurance Maladie (SNIIRAM) to the syst eme national des donn ees de sant e

. France, Rev Epidemiol Sante Publique, vol.65, pp.149-167, 2017.

D. Lefeuvre, J. Rudant, and S. Foulon, Healthcare expenditure of multiple sclerosis patients in 2013: a nationwide study based on French health administrative databases, Mult Scler J Exp Transl Clin, vol.3, p.2055217317730421, 2017.

J. Mourgues, Atlas of the medical demography in France on 1, Conseil National de L'Ordre des Medecins, 2017.

, by regions, departments, sex, and age from, Institut National de la Statistique et des É tudes É conomiques. Population estimates on 1, 1975.

N. Derache, A. Dufay, and C. Lebarbey, Organization of care for multiple sclerosis in France, Rev Neurol, vol.174, pp.475-479, 2018.

A. Fromont, M. Lehanneur, and F. Rollot, Cost of multiple sclerosis in France, Rev Neurol (Paris), vol.170, pp.432-439, 2014.

J. Roux, O. Grimaud, and E. Leray, Use of state sequence analysis for care pathway analysis: the example of multiple sclerosis, Stat Methods Med Res, vol.28, pp.1651-1663, 2019.
URL : https://hal.archives-ouvertes.fr/hal-01798652

, International Classification of Diseases, 10 th version (ICD-10) for the PMSI in France, 2015.

, Fonds de financement de la protection compl ementaire de la couverture universelle du risque maladie. Aid schemes to support healthcare access, 2018.

G. Rey, E. Jougla, and A. Fouillet, Ecological association between a deprivation index and mortality in France over the period 1997 -2001: Variations with spatial scale, degree of urbanicity, age, gender and cause of death, BMC Public Health, vol.9, issue.1, p.33, 2009.

A. Bannay, C. Chaignot, . Bloti, and . Po, The best use of the Charlson comorbidity index with electronic health care database to predict mortality, Med Care, vol.54, pp.188-194, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01817541

E. Kingwell, E. Leray, and F. Zhu, Multiple sclerosis: effect of beta interferon treatment on survival, Brain, vol.142, pp.1324-1333, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02088095

. R-core-team, R: A Language and Environment for Statistical Computing, 2015.

S. Vukusic, R. Casey, and F. Rollot, Observatoire Français de la Scl erose en Plaques (OFSEP): a unique multimodal nationwide MS registry in France, Mult Scler, p.135245851881560, 2018.

H. El-adssi, M. Debouverie, and F. Guillemin, Estimating the prevalence and incidence of multiple sclerosis in the Lorraine region, France, by the capture-recapture method, Mult Scler, vol.18, pp.1244-1250, 2012.

N. Chartier, J. Epstein, and M. Soudant, Clinical follow-up of 411 patients with relapsing and progressive multiple sclerosis 10 years after discontinuing mitoxantrone treatment: a real-life cohort study, Eur J Neurol, vol.25, pp.1439-1445, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02353098

M. Debouverie, L. Laforest, and E. Van-ganse, Earlier disability of the patients followed in multiple sclerosis centers compared to outpatients, Mult Scler, vol.15, pp.251-257, 2009.

, Organisation for Economic Cooperation and Development (OECD) Health Statistics. Health care utilisation, 2016.

S. L. Pohar, C. A. Jones, and S. Warren, Health status and health care utilization of multiple sclerosis in Canada, Can J Neurol Sci, vol.34, pp.167-174, 2007.

R. A. Marrie, N. Yu, and Y. Wei, High rates of physician services utilization at least five years before multiple sclerosis diagnosis, Mult Scler J, vol.19, pp.1113-1119, 2013.

G. Capkun, F. Dahlke, and R. Lahoz, Mortality and comorbidities in patients with multiple sclerosis compared with a population without multiple sclerosis: an observational study using the US Department of Defense administrative claims database, Mult Scler Relat Disord, vol.4, pp.546-554, 2015.

R. A. Marrie, L. Elliott, and J. Marriott, Comorbidity increases the risk of hospitalizations in multiple sclerosis, Neurology, vol.84, pp.350-358, 2014.

K. A. Mckay, R. A. Marrie, and J. D. Fisk, Comorbidities are associated with altered health services use in multiple sclerosis: a prospective cohort study, Neuroepidemiology, vol.51, pp.1-10, 2018.

K. A. Mckay, H. Tremlett, and F. Zhu, A populationbased study comparing multiple sclerosis clinic users and non-users in British Columbia, Canada, Eur J Neurol, vol.23, pp.1093-1100, 2016.

K. Harding, V. Anderson, and O. Williams, A contemporary study of mortality in the multiple sclerosis population of south east Wales, Mult Scler Relat Disord, vol.25, pp.186-191, 2018.

, Direction de la recherche, des etudes de l' evaluation et des statistiques (DREES). DATA.DREES -Etudes et statistiques, 2018.

R. Casey, F. Rollot, and M. Clanet, Observatoire Français de la Scl erose en Plaques (OFSEP): a powerful epidemiological tool, Mult Scler J, vol.23, pp.85-426, 2017.