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Poster communications
ChemPSy : Identification, classification et priorisation de nouveaux perturbateurs endocriniens par intégration massive de données de toxicogénomiques
Abstract : The aim of ChemPSy (Chemical Prioritization System) is to provide an innovative tool based on several bioinformatics and biostatistics methodologies to analyze and integrate massive toxicogenomics datasets. Specific objectives include: (1) classification of chemicals based on transcriptional signatures, i.e. the set of genes whose expression is known to be positively or negatively altered after an exposure to these compounds; (2) the association of classes with human pathologies or deleterious phenotypes, i.e. classes containing toxicants with well-known effects; (3) the prediction of novel reprotoxicants and/or endocrine disruptors based on transcriptional signature similarities with known chemicals affecting testis development and function.
(Intro.)
Mots-clés :
Perturbateurs endocriniens
ChemPSy
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02445078
Contributor : Chalmel Frédéric <>
Submitted on : Sunday, January 19, 2020 - 9:34:49 PM
Last modification on : Friday, July 10, 2020 - 4:17:20 PM
Contributor : Chalmel Frédéric <>
Submitted on : Sunday, January 19, 2020 - 9:34:49 PM
Last modification on : Friday, July 10, 2020 - 4:17:20 PM