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Plasmacytoma-like post-kidney-transplant lymphoproliferative disorder confined to renal allograft and urinary tract: A case report

Abstract : Post-transplantation lymphoproliferative disorder (PTLD) is a well-know complication after organ transplantation. We report a case of a patient who developed an extramedullary plasmacytoma-like PTLD around his transplanted kidney treated with standard multiple myeloma chemotherapy. Three years after benefiting of a deceased donor kidney transplant for an end stage kidney disease secondary to nephroangiosclerosis, our patient developed an extra-medullary plasmacytoma confined to the transplant compartment. The transplant function was unaltered, and due to the absence of reduction of the lesion after immunosuppression reduction, a chemotherapy by bortezomib-cyclophosphamide-dexamethasone (VCD) known to be efficient in multiple myeloma was initiated. After 6 cycles, positron emission tomography (PET) scan showed complete metabolic remission confirming the biological exams. This case report suggests that a chemotherapy such as VCD can efficiently treat plasmacytoma-like PTLD allowing graft survival. Therefore, transplant removal may not be mandatory as the best second line treatment after unsuccessfulness reduction of immunosuppression.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-02445398
Contributor : Cécile Vigneau <>
Submitted on : Monday, January 20, 2020 - 10:52:48 AM
Last modification on : Tuesday, March 3, 2020 - 3:45:34 PM

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Vincent Thibaud, Joseph Rivalan, Francisco Llamas, Mathilde Cherel, Olivier Decaux, et al.. Plasmacytoma-like post-kidney-transplant lymphoproliferative disorder confined to renal allograft and urinary tract: A case report. Néphrologie et Thérapeutique, Elsevier Masson, 2018, 14 (7), pp.544-547. ⟨10.1016/j.nephro.2018.07.404⟩. ⟨hal-02445398⟩

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