[Monitoring of hypertension in patients orally treated by angiogenesis inhibitor in daily practice].

Surveillance de l’hypertension artérielle chez les patients traités par anti-angiogénique par voie orale en pratique quotidienne

Lisa Belaid (1) , S. Bayat-Makoei (2, 3) , Brigitte Laguerre (4) , Cécile Vigneau (5, 6)

1 CH St Malo - Service de Néphrologie
2 REPERES - Recherche en Pharmaco-épidémiologie et Recours aux Soins
3 EHESP - École des Hautes Études en Santé Publique [EHESP]
4 CRLCC - Centre Eugène Marquis
5 CHU Pontchaillou [Rennes]
6 Irset - Institut de recherche en santé, environnement et travail

Objective - The aim of this study is to measure the monitoring and the incidence of renovascular effects of angiogenesis inhibitors in real population. Method - Are included in this descriptive, monocentric, practical study, patients of 18 years old and more, orally treated by angiogenesis inhibitors and monitored in consultation by clinician nurses. The main interest variable is the incidence of hypertension at three months of treatment. Results - From January, 2011 to July, 2014, 324 patients have been included, whose 53% are men. Mean age is 62±13 years old. Antecedents are: 37% of hypertension, 17% of chronic renal insufficiency, 21% of nephrectomy, 13% of diabetes. Most frequent cancers are kidney (31%), liver (23%) and breast (16%). Most used molecules are: sorafenib (30%), sunitinib (23%) and everolimus (16%). Blood pressure has been measured at the beginning of the treatment in 157 patients (48%). Among them, during the first three months of treatment, 55 (35%) present hypertension according to the oncological definition and 59 (38%) according to the classical definition; 30 patients (19%) are considered as hypertensive according to only one of the two definitions. In multivariable analysis, variables significantly associated with hypertension are: age (OR=1.04; 95% CI 1.02-1.08; P<0.01) and antecedent of nephrectomy (OR=4.29; 95%CI 1.86-9.92; P<0.01). Conclusion - In this cohort, only 48% of the patients had blood pressure determination before treatment. Hypertension under angiogenesis inhibitors is probably underestimated. Age and antecedent of nephrectomy seem to be correlated with the occurrence of hypertension.

Keywords: Angiogenesis inhibitors; Adverse effects; Effets indésirables; Hypertension artérielle; Hypertension; Insuffisance rénale; Inhibiteur de la tyrosine kinase; Inhibiteurs de l’angiogenèse; Molecular targeted therapy; Proteinuria; Protein-tyrosine kinases; Renal insufficiency; Protéinurie; Thérapie moléculaire ciblée

Domains: Life Sciences [q-bio]; Human health and pathology

Lisa Belaid, S. Bayat-Makoei, Brigitte Laguerre, Cécile Vigneau. Surveillance de l’hypertension artérielle chez les patients traités par anti-angiogénique par voie orale en pratique quotidienne. Néphrologie & Thérapeutique, 2018, 14 (2), pp.99-104. ⟨10.1016/j.nephro.2017.04.006⟩. ⟨hal-02445439⟩