Autoantibodies against podocytic UCHL1 are associated with idiopathic nephrotic syndrome relapses and induce proteinuria in mice

Agnès Jamin (1) , Laureline Berthelot (2) , Anne Couderc (3) , Jonathan Maurice M Chemouny , Erwan Boedec , Laurène Dehoux , Lilia Abbad , Claire Dossier (4) , Eric Daugas (5) , Renato C. Monteiro (1) , Georges Deschênes (6)

1 CRI (UMR_S_1149 / ERL_8252 / U1149) - Centre de recherche sur l'Inflammation
2 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie
3 IRICE - Identites, relations internationales et civilisations de l'Europe
4 UMRS893 - Centre de Recherche Saint-Antoine
5 UMR 1599
6 AP-HP, Service de Néphrologie Pédiatrique, Hôpital Robert Debré, Paris

Domains: Life Sciences [q-bio]; Immunology; Adaptive immunology; Life Sciences [q-bio]; Human health and pathology; Urology and Nephrology; Life Sciences [q-bio]; Human health and pathology; Pediatrics

Agnès Jamin, Laureline Berthelot, Anne Couderc, Jonathan Maurice M Chemouny, Erwan Boedec, et al.. Autoantibodies against podocytic UCHL1 are associated with idiopathic nephrotic syndrome relapses and induce proteinuria in mice. Journal of Autoimmunity, 2018, 89, pp.149-161. ⟨10.1016/j.jaut.2017.12.014⟩. ⟨hal-02445649⟩