The IgA1 immune complex–mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy

Houda Tamouza (1) , Jonathan Maurice M Chemouny , Leona Raskova Kafkova , Laureline Berthelot (2) , Martin Flamant (3) , Marie Demion (4) , Laurent Mesnard (5) , Etienne Paubelle (6) , Francine Walker (7) , Bruce Julian , Emilie Tissandie (1) , Meetu Tiwari , Niels O.S. Camara , François Vrtovsnik (8) , Marc Benhamou (9) , Jan Novak (10) , Renato C. Monteiro (11) , Ivan C. Moura (12)

1 Immunopathologie rénale, récepteurs et inflammation
2 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie
3 Service de Physiologie [Bichat-Claude Bernard]
4 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
5 Department of Physiology and Biophysics
6 Service Hématologie, CH LYON SUD, Pierre benite
7 Service d'Anatomie et cytologie pathologique
8 Service de Néphrologie [Bichat - Claude Bernard]
9 RIGHT - Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
10 Department of Microbiology
11 CRI (UMR_S_1149 / ERL_8252 / U1149) - Centre de recherche sur l'Inflammation
12 Service d'immuno-hématologie pédiatrique [CHU Necker]

Domains: Life Sciences [q-bio]; Human health and pathology; Urology and Nephrology; Life Sciences [q-bio]; Immunology; Adaptive immunology

Houda Tamouza, Jonathan Maurice M Chemouny, Leona Raskova Kafkova, Laureline Berthelot, Martin Flamant, et al.. The IgA1 immune complex–mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy. Kidney International, 2012, 82 (12), pp.1284-1296. ⟨10.1038/ki.2012.192⟩. ⟨hal-02445668⟩