Skip to Main content Skip to Navigation
Journal articles

Six-month outcomes of teduglutide treatment in adult patients with short bowel syndrome with chronic intestinal failure A real-world French observational cohort study

Abstract : Background & aims - Teduglutide, a GLP-2-analog, has proven effective in two placebo-controlled studies in reducing parenteral support (PS) in patients with short bowel syndrome-associated intestinal failure (SBS-IF) after 24 weeks. The aim of this study was to describe in a real-life situation the effects of teduglutide treatment and their predictive factors. Methods - We included 54 consecutive SBS-IF patients treated with teduglutide in France for at least 6 months from 10 expert centers. Small bowel length was 62 ± 6 cm and 65% had colon in continuity. PS was 4.4 ±0 .2 infusions per week, started 9.8 ± 1.2 years before. Response (PS reduction ≥ 20%) and PS discontinuation rates were assessed at week 24. Adjusted p values of factors associated with response and weaning were calculated using a multivariate logistic regression model. Results - At week 24, 85% of patients were responders and 24% had been weaned off PS, with a 51% reduction of PS needs and 1.5 ± 0.2 days off PS per week. Response to teduglutide was influenced by a higher baseline oral intake (p = 0.02). Weaning off PS was influenced by the presence of colon (p = 0.04), a lower PS volume (p = 0.03) and a higher oral intake (p = 0.01). There were no differences based on age, bowel length or SBS-IF causes. Conclusions - Our study confirms the effectiveness of teduglutide in reducing PS needs in SBS-IF patients. We associated reduced parenteral support volume with baseline parenteral volume support, bowel anatomy, and oral intake. These findings underline the role of nutritional optimization when starting the treatment.
Document type :
Journal articles
Complete list of metadatas

https://hal-univ-rennes1.archives-ouvertes.fr/hal-02472237
Contributor : Laurent Jonchère <>
Submitted on : Monday, February 10, 2020 - 10:00:32 AM
Last modification on : Friday, October 16, 2020 - 3:30:35 AM

Identifiers

Citation

F Joly, D Seguy, A Nuzzo, C Chambrier, P Beau, et al.. Six-month outcomes of teduglutide treatment in adult patients with short bowel syndrome with chronic intestinal failure A real-world French observational cohort study. Clinical Nutrition, Elsevier, 2019, ⟨10.1016/j.clnu.2019.12.019⟩. ⟨hal-02472237⟩

Share

Metrics

Record views

317