Synthesis and Biological Evaluation of Four New Ricinoleic Acid-Derived 1-O-alkylglycerols

René Momha (1, 2) , Victor Kuete (3, 4) , Jean-Marie Pagès (4) , Dieudonné Emmanuel Pegnyemb (5) , Paul Mosset (1)

1 ISCR - Institut des Sciences Chimiques de Rennes
2 AGIR - Agents infectieux, résistance et chimiothérapie - UR UPJV 4294
3 Université de Dschang
4 MCT - Membranes et cibles thérapeutiques
5 UY1 - Université de Yaoundé I

A series of novel substituted 1--alkylglycerols (AKGs) containing methoxy (), -difluoro (), azide () and hydroxy () group at 12 position in the alkyl chain were synthesized from commercially available ricinoleic acid (). The structures of these new synthesized AKGs were established by NMR experiments as well as from the HRMS and elementary analysis data. The antimicrobial activities of the studied AKGs - were evaluated, respectively, and all compounds exhibited antimicrobial activity to different extents alone and also when combined with some commonly used antibiotics (gentamicin, tetracycline, ciprofloxacin and ampicillin). AKG was viewed as a lead compound for this series as it exhibited significantly higher antimicrobial activity than compounds -.

Mots clés: structure–activity relationship (SAR) studies; antimicrobial activity; ciprofloxacin and ampicillin); ricinoleic acid (RA); tetracycline; alkylglycerol (AKG); antibiotics (gentamicin

Domaines: Chimie

René Momha, Victor Kuete, Jean-Marie Pagès, Dieudonné Emmanuel Pegnyemb, Paul Mosset. Synthesis and Biological Evaluation of Four New Ricinoleic Acid-Derived 1-O-alkylglycerols. Marine drugs, 2020, 18 (2), ⟨10.3390/md18020113⟩. ⟨hal-02498785⟩