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Antibiotic resistance: Tools for effective translational research

Marie-Cécile Ploy 1, * Antoine Andremont 2 Bruno Valtier 3 Claire Le Jeunne 4 Catherine Dumartin 5, 6 Didier Guillemot 7, 8 Alain Bousquet-Mélou 9 Christian Brun-Buisson 7 Bruno Coignard 10 Didier Concordet 9 William Couet 11 Joanie del Bano 12, 13 Romain Guilhaumou 12, 13 Cyril Guyard 14 Evelyne Jouvin-Marche 15 Solen Kernéis 4, 7 Mohamed Khelifa 16 Mourez Michaël 17 Marie-Clémence Verdier 18, 19
* Corresponding author
1 RESINFIT - Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques
2 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
3 Pfizer
4 CHU Cochin [AP-HP]
5 BPH - Bordeaux population health
6 CHU Bordeaux [Bordeaux]
7 B2PHI - Biostatistique, Biomathématique, Pharmacoépidémiologie et Maladies Infectieuses
8 Hôpital Raymond Poincaré [AP-HP]
9 InTheRes - Innovations Thérapeutiques et Résistances
10 Direction des maladies infectieuses [Saint-Maurice]
11 PHAR - Pharmacologie des anti-infectieux
12 Service de Pharmacologie Clinique [Hôpital de la Timone - APHM]
APHM - Assistance Publique - Hôpitaux de Marseille, TIMONE - Hôpital de la Timone [CHU - APHM]
13 CRPV-Marseille - Centre régional de pharmacovigilance de Marseille Provence Corse [CHU de Marseille]
14 BIOASTER [Lyon]
15 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
16 Sanofi-Aventis R&D
17 Evotec
18 CIC - Centre d'Investigation Clinique [Rennes]
19 CHU Pontchaillou [Rennes]
Abstract : The rising emergence of bacterial resistances has led to a crisis which threatens human, animal and environmental health. The impact of the emergency is enormous in terms of public health and economics. Although there is a global awareness of the warnings and programmes supporting innovative actions to combat fight against antibiotic resistance, it must be admitted that proposed new antibiotics fail to find the economic profitability necessary for them to reach the market and become available for patients and the community. Moreover, it is necessary to develop tools/indicators to define effective interventions against antibiotic resistance. The work of the think-tank reported in this article concentrated on two aspects of translational research: - prevention and the impact on health of the antibiotic resistance issue, and - the specific requirements of clinical research leading to innovation in the fight against antibiotic resistance. This article, which reflects the thoughts of a group of French experts, proposes directly operational solutions which could be rapidly implemented and radically transform the quality and quantity of our resources available for the combat.
Keywords : Innovation Antibio-resistance Impact Stewardship Microbiota
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Marie-Cécile Ploy, Antoine Andremont, Bruno Valtier, Claire Le Jeunne, Catherine Dumartin, et al.. Antibiotic resistance: Tools for effective translational research. Thérapie, EDP Sciences, 2020, Giens Workshops 2019, 75 (1), pp.7-12. ⟨10.1016/j.therap.2019.12.003⟩. ⟨hal-02516924⟩

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