Cancer risk in dialyzed patients with and without diabetes

Adélaide Pladys (1) , Gautier Defossez (2) , Pierre Lemordant (3) , Mathilde Lassalle (4) , Pierre Ingrand (2) , Christian Jacquelinet (5) , Christine Riou (3) , Guillaume Bouzillé (3) , Pascal van Hille (3) , Cécile Vigneau (6) , Marc Cuggia (3) , Sahar Bayat (1)

1 REPERES - Recherche en Pharmaco-épidémiologie et Recours aux Soins
2 CIC 1402 - CIC Poitiers – Centre d'investigation clinique de Poitiers
3 LTSI - Laboratoire Traitement du Signal et de l'Image
4 Agence de la biomédecine [Saint-Denis la Plaine]
5 CESP - Centre de recherche en épidémiologie et santé des populations
6 Irset - Institut de recherche en santé, environnement et travail

BackgroundThe risk of cancer is higher in patients with renal diseases and diabetes compared with the general population. The aim of this study was to assess in dialyzed patients, the association between diabetes and the risk to develop a cancer after dialysis start.MethodsAll patients who started dialysis in the French region of Poitou-Charentes between 2008 and 2015 were included. Their baseline characteristics were extracted from the French Renal Epidemiology and Information Network and were linked to data relative to cancer occurrence from the Poitou-Charentes General Cancer Registry using a procedure developed by the INSHARE platform. The association between diabetes and the risk of cancer was assessed using the Fine & Gray model that takes into account the competing risk of death.ResultsAmong the 1634 patients included, 591 (36.2 %) had diabetes and 91 (5.6 %) patients developed a cancer (n = 24 before or at dialysis start, and n = 67 after dialysis start). The risk to develop a cancer after dialysis initiation was lower in dialyzed patients with diabetes than without diabetes (SHR = 0.54; 95 %CI: 0.32-0.91). Moreover, compared with the general population, the cancer risk was higher in dialyzed patients without diabetes, but not in those with diabetes.ConclusionThe risk of developing a cancer in the region of Poitou-Charentes is higher in dialyzed patients without diabetes than with diabetes.

Mots clés: Cancer occurrence; Cancer registry; Diabetes; End stage renal disease; INSHARE platform; REIN registry

Domaines: Sciences du Vivant [q-bio]; Santé publique et épidémiologie

Adélaide Pladys, Gautier Defossez, Pierre Lemordant, Mathilde Lassalle, Pierre Ingrand, et al.. Cancer risk in dialyzed patients with and without diabetes. Cancer Epidemiology, 2020, 65, pp.101689. ⟨10.1016/j.canep.2020.101689⟩. ⟨hal-02534803⟩