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Journal articles
A novel benzodiazepine derivative that suppresses microtubule dynamics and impairs mitotic progression
Abstract : A novel 2,3-benzodiazepine-4 derivative, named 1g, has recently been shown to function as an anti-proliferative compound. We now show that it perturbs the formation of a functional mitotic spindle, inducing a spindle assembly checkpoint (SAC)-dependent arrest in human cells. Live analysis of individual microtubules indicates that 1g promotes a rapid and reversible reduction in microtubule growth. Unlike most anti-mitotic compounds, we found that 1g does not interfere directly with tubulin or perturb microtubule assembly in vitro The observation that 1g also triggers a SAC-dependent mitotic delay associated with chromosome segregation in Drosophila neural stem cells, suggests that it targets a conserved microtubule regulation module in humans and flies. Altogether, our results indicate that 1g is a novel promising anti-mitotic drug with the unique properties of altering microtubule growth and mitotic spindle organization.
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02543756
Contributor : Laurent Jonchère <>
Submitted on : Friday, April 17, 2020 - 10:13:00 AM
Last modification on : Wednesday, October 14, 2020 - 4:01:51 AM
Contributor : Laurent Jonchère <>
Submitted on : Friday, April 17, 2020 - 10:13:00 AM
Last modification on : Wednesday, October 14, 2020 - 4:01:51 AM
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Benaud-2020-A novel benzodiaze...
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