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Echocardiographic reference ranges for normal left ventricular layer-specific strain: results from the EACVI NORRE study

Abstract : Aims  - To obtain the normal range for 2D echocardiographic (2DE) measurements of left ventricular (LV) layer-specific strain from a large group of healthy volunteers of both genders over a wide range of ages. Methods and results  - A total of 287 (109 men, mean age: 46 ± 14 years) healthy subjects were enrolled at 22 collaborating institutions of the EACVI Normal Reference Ranges for Echocardiography (NORRE) study. Layer-specific strain was analysed from the apical two-, three-, and four-chamber views using 2DE software. The lowest values of layer-specific strain calculated as ±1.96 standard deviations from the mean were -15.0% in men and -15.6% in women for epicardial strain, -16.8% and -17.7% for mid-myocardial strain, and -18.7% and -19.9% for endocardial strain, respectively. Basal-epicardial and mid-myocardial strain decreased with age in women (epicardial; P = 0.008, mid-myocardial; P = 0.003) and correlated with age (epicardial; r = -0.20, P = 0.007, mid-myocardial; r = -0.21, P = 0.006, endocardial; r = -0.23, P = 0.002), whereas apical-epicardial, mid-myocardial strain increased with the age in women (epicardial; P = 0.006, mid-myocardial; P = 0.03) and correlated with age (epicardial; r = 0.16, P = 0.04). End/Epi ratio at the apex was higher than at the middle and basal levels of LV in men (apex; 1.6 ± 0.2, middle; 1.2 ± 0.1, base 1.1 ± 0.1) and women (apex; 1.6 ± 0.1, middle; 1.1 ± 0.1, base 1.2 ± 0.1). Conclusion  - The NORRE study provides useful 2DE reference ranges for novel indices of layer-specific strain.
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Submitted on : Tuesday, May 5, 2020 - 9:59:50 AM
Last modification on : Wednesday, August 26, 2020 - 4:19:36 PM

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Toshimitsu Tsugu, Adriana Postolache, Raluca Dulgheru, Tadafumi Sugimoto, Julien Tridetti, et al.. Echocardiographic reference ranges for normal left ventricular layer-specific strain: results from the EACVI NORRE study. European Heart Journal - Cardiovascular Imaging, Oxford UP, 2020, 21 (8), pp.896-905. ⟨10.1093/ehjci/jeaa050⟩. ⟨hal-02563106⟩

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