Y. Toya and H. Shimizu, Flux Analysis and Metabolomics for Systematic Metabolic Engineering of Microorganisms, Bioenergy Biorefinery Biomass Innov. Technol. Dev, issue.6, pp.818-826, 2013.

,

M. A. Keibler, S. Fendt, and G. Stephanopoulos, Expanding the Concepts and Tools of Metabolic Engineering to Elucidate Cancer Metabolism, Biotechnol. Prog, vol.2012, issue.6, pp.1409-1418

D. C. Sévin, A. Kuehne, N. Zamboni, and U. Sauer, Biological Insights through Nontargeted Metabolomics. Syst. Biol. ? Nanobiotechnology, vol.34, pp.1-8, 2015.

S. Heux, C. Bergès, P. Millard, J. Portais, and F. Létisse, Advances in High-Throughput 13C-Fluxomics, vol.43, pp.104-109, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01604972

D. Christodoulou, A. Kuehne, A. Estermann, T. Fuhrer, P. Lang et al., Reserve Flux Capacity in the Pentose Phosphate Pathway by NADPH Binding Is Conserved across Kingdoms, vol.19, pp.1133-1144, 2019.

J. M. Buescher, M. R. Antoniewicz, L. G. Boros, S. C. Burgess, H. Brunengraber et al.,

, Metabolite Labeling Patterns from Cells, Curr. Opin. Biotechnol, vol.34, pp.189-201, 2015.

P. Millard, U. Schmitt, P. Kiefer, J. A. Vorholt, S. Heux et al., A Scalable Approach to Quantify Fluxes in Metabolic Subnetworks. bioRxiv, vol.735308, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02306115

B. Delépine, M. G. López, M. Carnicer, C. M. Vicente, V. F. Wendisch et al., Charting the Metabolic Landscape of the Facultative Methylotroph <em>Bacillus Methanolicus</Em>, vol.858514, 2019.

Y. Xu, D. Amador-noguez, M. L. Reaves, X. Feng, and J. D. Rabinowitz, Ultrasensitive Regulation of Anapleurosis via Allosteric Activation of PEP Carboxylase, Nat. Chem. Biol, vol.2012, issue.6, pp.562-568

B. Enjalbert, P. Millard, M. Dinclaux, J. Portais, and F. Létisse, Acetate Fluxes in Escherichia Coli Are Determined by the Thermodynamic Control of the Pta-AckA Pathway, Sci. Rep, vol.7, pp.42135-42135, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01605965

P. Millard, J. Portais, and P. Mendes, Impact of Kinetic Isotope Effects in Isotopic Studies of Metabolic Systems, BMC Syst. Biol, vol.2015, issue.1, p.64
URL : https://hal.archives-ouvertes.fr/hal-01269427

P. Millard, K. Smallbone, and P. Mendes, Metabolic Regulation Is Sufficient for Global and Robust Coordination of Glucose Uptake, Catabolism, Energy Production and Growth in Escherichia Coli
URL : https://hal.archives-ouvertes.fr/hal-01608610

, Comput. Biol, vol.2017, issue.2, pp.1005396-1005396

B. D. Bennett, J. Yuan, E. H. Kimball, and J. D. Rabinowitz, Absolute Quantitation of Intracellular Metabolite Concentrations by an Isotope Ratio-Based Approach, Nat. Protoc, vol.3, issue.8, pp.1299-1311, 2008.

L. Wu, M. R. Mashego, J. C. Van-dam, A. M. Proell, J. L. Vinke et al., Quantitative Analysis of the Microbial Metabolome by Isotope Dilution Mass Spectrometry Using Uniformly 13C-Labeled Cell Extracts as Internal Standards, Anal. Biochem, vol.336, issue.2, pp.164-171, 2005.

L. You, B. Zhang, and Y. J. Tang, Application of Stable Isotope-Assisted Metabolomics for, Cell Metabolism Studies. Metabolites, vol.2014, issue.2, pp.142-165

W. Lu, X. Su, M. S. Klein, I. A. Lewis, O. Fiehn et al., Metabolite Measurement: Pitfalls to Avoid and Practices to Follow, Annu. Rev. Biochem, vol.2017, issue.1, pp.277-304

D. Weindl, A. Wegner, C. Jäger, and K. Hiller, Isotopologue Ratio Normalization for Non-Targeted Metabolomics, J. Chromatogr. A, vol.1389, pp.112-119, 2015.

C. Patacq, N. Chaudet, and F. Létisse, Absolute Quantification of PpGpp and PppGpp by Double-Spike Isotope Dilution Ion Chromatography-High-Resolution Mass Spectrometry, Anal. Chem, issue.18, pp.10715-10723, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01956108

A. D. Hegeman, C. F. Schulte, Q. Cui, I. A. Lewis, E. L. Huttlin et al., Stable Isotope Assisted Assignment of Elemental Compositions for Metabolomics, Anal. Chem, issue.18, pp.6912-6921, 2007.

P. Millard, S. Massou, C. Wittmann, J. Portais, and F. Létisse, Sampling of Intracellular Metabolites for Stationary and Non-Stationary (13)C Metabolic Flux Analysis in Escherichia Coli, Anal. Biochem, vol.465, pp.38-49, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01268941

M. Heuillet, F. Bellvert, E. Cahoreau, F. Letisse, P. Millard et al., Methodology for the Validation of Isotopic Analyses by Mass Spectrometry in Stable-Isotope Labeling Experiments, Anal. Chem, vol.90, issue.3, pp.1852-1860, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01886456

M. R. Mashego, L. Wu, J. C. Van-dam, C. Ras, J. L. Vinke et al., Mass Isotopomer Ratio Analysis of U-13C-Labeled Extracts. A New Method for Accurate Quantification of Changes in Concentrations of Intracellular Metabolites, Biotechnol. Bioeng, vol.85, issue.6, pp.620-628, 2004.

L. E. Sojo, G. Lum, and P. Chee, Internal Standard Signal Suppression by Co-Eluting Analyte in Isotope Dilution LC-ESI-MS, Analyst, vol.128, issue.1, pp.51-54, 2003.

P. Kiefer, J. Portais, and J. A. Vorholt, Quantitative Metabolome Analysis Using Liquid Chromatography-High-Resolution Mass Spectrometry, Anal. Biochem, vol.382, issue.2, pp.94-100, 2008.

P. Millard, B. Delépine, M. Guionnet, M. Heuillet, F. Bellvert et al., IsoCor: Isotope Correction for High-Resolution MS Labeling Experiments, Bioinformatics, vol.2019, issue.21, pp.4484-4487
URL : https://hal.archives-ouvertes.fr/hal-02084784

S. Khodjaniyazova, M. Nazari, K. P. Garrard, M. P. Matos, G. P. Jackson et al., Characterization of the Spectral Accuracy of an Orbitrap Mass Analyzer Using Isotope Ratio Mass Spectrometry, Anal. Chem, vol.90, issue.3, pp.1897-1906, 2018.

X. Su, W. Lu, and J. D. Rabinowitz, Metabolite Spectral Accuracy on Orbitraps, Anal. Chem, vol.2017, issue.11, pp.5940-5948

P. Millard, S. Massou, J. Portais, and F. Létisse, Isotopic Studies of Metabolic Systems by Mass Spectrometry: Using Pascal's Triangle to Produce Biological Standards with Fully Controlled Labeling Patterns, Anal. Chem, vol.86, issue.20, pp.10288-10295, 2014.

H. P. Harding, Y. Zhang, H. Zeng, I. Novoa, P. D. Lu et al., An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress, Mol. Cell, vol.11, issue.3, pp.105-114, 2003.

M. Miyake, M. Kuroda, H. Kiyonari, K. Takehana, S. Hisanaga et al., Ligand-Induced Rapid Skeletal Muscle Atrophy in HSA-Fv2E-PERK Transgenic Mice, PloS One, vol.12, issue.6, pp.179955-0179955, 2017.

A. Huber, J. Lebeau, P. Guillaumot, V. Pétrilli, M. Malek et al., P58IPK-Mediated Attenuation of the Proapoptotic PERK-CHOP Pathway Allows Malignant Progression upon Low Glucose, Mol. Cell, issue.6, pp.1049-1059, 2013.

H. Eagle, The Specific Amino Acid Requirements of Mammalian Cell (Strain L) in Tissue Culture, J. Biol. Chem, vol.214, pp.839-852, 1955.

C. Jang, L. Chen, and J. D. Rabinowitz, Metabolomics and Isotope Tracing. Cell, vol.173, issue.4, pp.822-837, 2018.