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PROGNOSTIC VALUE OF POSTTREATMENT FEDG-PET IMAGING FOLLOWING COMBINED CHEMORADIATION THERAPY IN LOCALLY ADVANCED CERVICAL CANCER

Sophie Knight 1 Julien Mancini 2 Cyril Touboul 3 Pierre Adrien Bolze 4 Sofiane Bendifallah 5 Marcos Ballester 6 Pierre Collinet 7 Yohan Kerbage 8 Lobna Ouldamer 9 Geoffroy Atrous 9 Vincent Lavoue 10 Ludivine Dion 10 Yohann Dabi 3 Emilie Raimond 11 Olivier Graesslin 11 Cyrille Huchon 12 Myriam Mimouni 12 Alexandre Bricou 13 Francois Golfier 4 Xavier Carcopino 1
1 IMBE - Institut méditerranéen de biodiversité et d'écologie marine et continentale
2 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
3 CHIC - Centre Hospitalier Intercommunal de Créteil
4 HCL - Hospices Civils de Lyon
5 Service de Gynécologie-Obstétrique [CHU Tenon]
6 Groupe Hospitalier Diaconesses Croix Saint-Simon
7 CHRU Lille - Centre Hospitalier Régional Universitaire [Lille]
8 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
9 N2C - Nutrition, croissance et cancer (U 1069)
10 COSS - Chemistry, Oncogenesis, Stress and Signaling
11 CHU Reims - Centre Hospitalier Universitaire de Reims
12 RISCQ - Risques cliniques et sécurité en santé des femmes et en santé périnatale
13 CECOS - Centre d’Études et de Conservation des Œufs et du Sperme [CHU Jean Verdier]
Abstract : Objectives - To evaluate the performances of posttreatment FEDG-PET to predict the prognosis of patients treated with concurrent chemoradiotherapy (CT/RT) for locally advanced cervical cancer. Materials and methods - The medical records of 131 patients treated in 9 French academic institutions for IB2-IIB cervical cancer and for which a posttherapy FEDG-PET was performed were reviewed. All patients received CT/RT, possibly completed with vaginal brachytherapy (VBT) and completion surgery. Posttreatment FEDG-PET was performed within 3 months after completion of CT/RT or VBT. Incomplete metabolic response (IMR) was defined as the persistence of FEDG uptake. Results - An IMR was identified in 44 (33.6 %) cases. IMR was associated with higher risk of recurrence (aHR = 2.8; 95 %CI: 1.3-5.7; p = 0.006) and death (aHR = 4.5 ;95 %CI: 1.4-13.8; p = 0.009). Completion surgery was performed in 61 (46.9 %) patients with histologic cervical residual disease identified in 31 (50.8 %). FEDG-PET sensitivity and specificity in predicting cervical residual disease following CT/RT was 48.4 % (95 %CI: 30.8-66) and 80 % (95 %CI: 65.7-94.3), respectively. Conclusions - In patients treated with CT/RT for locally advanced cervical cancer, despite limited performances to predict cervical residual disease, posttreatment FEDG-PET is predictive of patients' prognosis and long-term outcome.
Keywords : Cervical cancer FEDG-PET chemoradiation prognosis
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-02563844
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Submitted on : Tuesday, May 19, 2020 - 4:01:15 PM
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BIOSIT | UVSQ | FNCLCC | CNRS | UR1-UFR-SVE | UNIV-RENNES | IMBE | UNIV-AMU | MARQUIS | UNIV-AVIGNON | UNIV-RENNES1 | UNIV-TOURS | HCL | OSS | IMBE-BES | RISCQ | U1252 | IRD | OSU-INSTITUT-PYTHEAS | SORBONNE-UNIVERSITE | SU-TI

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Sophie Knight, Julien Mancini, Cyril Touboul, Pierre Adrien Bolze, Sofiane Bendifallah, et al.. PROGNOSTIC VALUE OF POSTTREATMENT FEDG-PET IMAGING FOLLOWING COMBINED CHEMORADIATION THERAPY IN LOCALLY ADVANCED CERVICAL CANCER. Journal of Gynecology Obstetrics and Human Reproduction, Elsevier, 2020, 49 (8), pp.101774. ⟨10.1016/j.jogoh.2020.101774⟩. ⟨hal-02563844⟩

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