PROGNOSTIC VALUE OF POSTTREATMENT FEDG-PET IMAGING FOLLOWING COMBINED CHEMORADIATION THERAPY IN LOCALLY ADVANCED CERVICAL CANCER

Sophie Knight (1) , Julien Mancini (2) , Cyril Touboul (3) , Pierre Adrien Bolze (4) , Sofiane Bendifallah (5) , Marcos Ballester (6) , Pierre Collinet (7) , Yohan Kerbage (8) , Lobna Ouldamer (9) , Geoffroy Atrous (9) , Vincent Lavoue (10) , Ludivine Dion (10) , Yohann Dabi (3) , Emilie Raimond (11) , Olivier Graesslin (11) , Cyrille Huchon (12) , Myriam Mimouni (12) , Alexandre Bricou (13) , Francois Golfier (4) , Xavier Carcopino (1)

1 IMBE - Institut méditerranéen de biodiversité et d'écologie marine et continentale
2 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
3 CHIC - Centre Hospitalier Intercommunal de Créteil
4 HCL - Hospices Civils de Lyon
5 Service de Gynécologie-obstétrique et médecine de la reproduction - Maternité [CHU Tenon]
6 Groupe Hospitalier Diaconesses Croix Saint-Simon
7 CHRU Lille - Centre Hospitalier Régional Universitaire [Lille]
8 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
9 N2C - Nutrition, croissance et cancer (U 1069)
10 COSS - Chemistry, Oncogenesis, Stress and Signaling
11 CHU Reims - Centre Hospitalier Universitaire de Reims
12 RISCQ - Risques cliniques et sécurité en santé des femmes et en santé périnatale
13 CECOS - Centre d’Études et de Conservation des Œufs et du Sperme [CHU Jean Verdier]

Objectives - To evaluate the performances of posttreatment FEDG-PET to predict the prognosis of patients treated with concurrent chemoradiotherapy (CT/RT) for locally advanced cervical cancer. Materials and methods - The medical records of 131 patients treated in 9 French academic institutions for IB2-IIB cervical cancer and for which a posttherapy FEDG-PET was performed were reviewed. All patients received CT/RT, possibly completed with vaginal brachytherapy (VBT) and completion surgery. Posttreatment FEDG-PET was performed within 3 months after completion of CT/RT or VBT. Incomplete metabolic response (IMR) was defined as the persistence of FEDG uptake. Results - An IMR was identified in 44 (33.6 %) cases. IMR was associated with higher risk of recurrence (aHR = 2.8; 95 %CI: 1.3-5.7; p = 0.006) and death (aHR = 4.5 ;95 %CI: 1.4-13.8; p = 0.009). Completion surgery was performed in 61 (46.9 %) patients with histologic cervical residual disease identified in 31 (50.8 %). FEDG-PET sensitivity and specificity in predicting cervical residual disease following CT/RT was 48.4 % (95 %CI: 30.8-66) and 80 % (95 %CI: 65.7-94.3), respectively. Conclusions - In patients treated with CT/RT for locally advanced cervical cancer, despite limited performances to predict cervical residual disease, posttreatment FEDG-PET is predictive of patients' prognosis and long-term outcome.

Keywords: Cervical cancer; FEDG-PET; chemoradiation; prognosis

Domains: Life Sciences [q-bio]; Cancer

Sophie Knight, Julien Mancini, Cyril Touboul, Pierre Adrien Bolze, Sofiane Bendifallah, et al.. PROGNOSTIC VALUE OF POSTTREATMENT FEDG-PET IMAGING FOLLOWING COMBINED CHEMORADIATION THERAPY IN LOCALLY ADVANCED CERVICAL CANCER. Journal of Gynecology Obstetrics and Human Reproduction, 2020, 49 (8), pp.101774. ⟨10.1016/j.jogoh.2020.101774⟩. ⟨hal-02563844⟩