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Journal articles
PROGNOSTIC VALUE OF POSTTREATMENT FEDG-PET IMAGING FOLLOWING COMBINED CHEMORADIATION THERAPY IN LOCALLY ADVANCED CERVICAL CANCER
Sophie Knight
1
Julien Mancini
2
Cyril Touboul
3
Pierre Adrien Bolze
4
Sofiane Bendifallah
5
Marcos Ballester
6
Pierre Collinet
7
Yohan Kerbage
8
Lobna Ouldamer
9
Geoffroy Atrous
9
Vincent Lavoue
10
Ludivine Dion
10
Yohann Dabi
Emilie Raimond
11
Olivier Graesslin
11
Cyrille Huchon
12
Myriam Mimouni
12
Alexandre Bricou
13
Francois Golfier
4
Xavier Carcopino
1
Sophie Knight 1
Author
Julien Mancini 2
Mail :
Author IdHAL : julien-mancini ResearcherId : http://www.researcherid.com/rid/G-6263-2011 ORCID : https://orcid.org/0000-0001-9500-8598
Cyril Touboul 3
Author
Pierre Adrien Bolze 4
Author
Sofiane Bendifallah 5
Author
Marcos Ballester 6
Author
Pierre Collinet 7
Author
Yohan Kerbage 8
Author
Myriam Mimouni 12
Author
Alexandre Bricou 13
Author
Francois Golfier 4
Author
Xavier Carcopino 1
Mail :
Author IdHAL : xavier-carcopino ORCID : https://orcid.org/0000-0002-9533-3558
1
IMBE - Institut méditerranéen de biodiversité et d'écologie marine et continentale (Aix Marseille Université, Campus Etoile, Faculté St-Jérôme case 421 Av. . escadrille Normandie-Niemen 13397 MARSEILLE CEDEX 20 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7263 (France)
- Institut de recherche pour le développement [IRD] : UMR237 : UMR7263 (France)
- AMU - Aix Marseille Université : UMR7263 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- AU - Avignon Université : UMR7263 (74 rue Louis Pasteur - 84 029 Avignon cedex 1 - France)
2
SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (Faculté de Médecine - Site Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 05. - France)
- IRD - Institut de Recherche pour le Développement : UMR 259 (Siège Le Sextant 44, bd de Dunkerque CS 90009 13572 Marseille cedex 02 - France)
- AMU - Aix Marseille Université (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1252 (101, rue de Tolbiac, 75013 Paris - France)
3
CHIC - Centre Hospitalier Intercommunal de Créteil (40 Avenue de Verdun 94000 Créteil - France)
4
HCL - Hospices Civils de Lyon (3 Quai des Célestins
69002 Lyon - France)
5
Service de Gynécologie-Obstétrique [CHU Tenon] (4 rue de la Chine, 75020 Paris - France)
- APHP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Tenon [APHP] (4 Rue de la Chine, 75020 Paris - France)
6
Groupe Hospitalier Diaconesses Croix Saint-Simon (18 rue du Sergent Bauchat
75012 PARIS - France)
7
CHRU Lille - Centre Hospitalier Régional Universitaire [Lille] (2, avenue Oscar Lambret - 59037 Lille Cedex - France)
9
N2C - Nutrition, croissance et cancer (U 1069) (Faculté de médecine, 10 Bd Tonnelle 37032 Tours Cedex 1 - France)
- Université de Tours (60 rue du Plat d'Étain, 37020 Tours cedex 1 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1069 (101, rue de Tolbiac, 75013 Paris - France)
10
COSS - Chemistry, Oncogenesis, Stress and Signaling (Université de Rennes1 - CLCC Eugène Marquis, Rue de la Bataille Flandres Dunkerque, Bat D, 35042 Rennes - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
- CRLCC - CRLCC Eugène Marquis (Avenue Bataille Flandres-Dunkerque 35042 RENNES CEDEX - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1242 (101, rue de Tolbiac, 75013 Paris - France)
11
CHU Reims - Centre Hospitalier Universitaire de Reims (45, rue Cognacq-Jay 51100 Reims - France)
12
RISCQ - Risques cliniques et sécurité en santé des femmes et en santé périnatale (UFR Simone Veil
2 avenue de la source de la Bièvre
78180 Montigny-le-Bretonneux
- France)
- UVSQ - Université de Versailles Saint-Quentin-en-Yvelines : UR7285 (55 avenue de Paris - 78035 Versailles cedex - France)
13
CECOS - Centre d’Études et de Conservation des Œufs et du Sperme [CHU Jean Verdier] (Hôpital Jean Verdier - Avenue de 14 juillet - 93140 Bondy - France)
- AP-HP Hôpital Jean-Verdier [Bondy] (avenue du 14 juillet 93143 Bondy cedex - France)
Abstract : OBJECTIVES:
To evaluate the performances of posttreatment FEDG-PET to predict the prognosis of patients treated with concurrent chemoradiotherapy (CT/RT) for locally advanced cervical cancer.
MATERIALS AND METHODS:
The medical records of 131 patients treated in 9 French academic institutions for IB2-IIB cervical cancer and for which a posttherapy FEDG-PET was performed were reviewed. All patients received CT/RT, possibly completed with vaginal brachytherapy (VBT) and completion surgery. Posttreatment FEDG-PET was performed within 3 months after completion of CT/RT or VBT. Incomplete metabolic response (IMR) was defined as the persistence of FEDG uptake.
RESULTS:
An IMR was identified in 44 (33.6%) cases. IMR was associated with higher risk of recurrence (aHR = 2.8; 95%CI: 1.3-5.7; p = 0.006) and death (aHR = 4.5 ;95%CI: 1.4-13.8; p = 0.009). Completion surgery was performed in 61 (46.9%) patients with histologic cervical residual disease identified in 31 (50.8%). FEDG-PET sensitivity and specificity in predicting cervical residual disease following CT/RT was 48.4% (95%CI: 30.8-66) and 80% (95%CI: 65.7-94.3), respectively.
CONCLUSIONS:
In patients treated with CT/RT for locally advanced cervical cancer, despite limited performances to predict cervical residual disease, posttreatment FEDG-PET is predictive of patients' prognosis and long-term outcome.
Document type :
Journal articles
Domain :
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-02563844
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, May 19, 2020 - 4:01:15 PM
Last modification on : Thursday, June 11, 2020 - 4:19:34 AM
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, May 19, 2020 - 4:01:15 PM
Last modification on : Thursday, June 11, 2020 - 4:19:34 AM
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Identifiers
- HAL Id : hal-02563844, version 1
- DOI : 10.1016/j.jogoh.2020.101774
- PUBMED : 32330672
Collections
IMBE-BES | BIOSIT | OSS | RISCQ | UR1-UFR-SVE | UNIV-RENNES | U1252 | UVSQ | CNRS | UNIV-RENNES1 | UNIV-TOURS | UNIV-AVIGNON | HCL | UNIV-AMU | FNCLCC | MARQUIS | IMBE | IRD | OSU-INSTITUT-PYTHEAS | UNIV-PARIS-SACLAY
Citation
Sophie Knight, Julien Mancini, Cyril Touboul, Pierre Adrien Bolze, Sofiane Bendifallah, et al.. PROGNOSTIC VALUE OF POSTTREATMENT FEDG-PET IMAGING FOLLOWING COMBINED CHEMORADIATION THERAPY IN LOCALLY ADVANCED CERVICAL CANCER. Journal of Gynecology Obstetrics and Human Reproduction, Elsevier, 2020, pp.101774. ⟨10.1016/j.jogoh.2020.101774⟩. ⟨hal-02563844⟩
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