Adherens junctions: from molecules to morphogenesis, Nature reviews Molecular cell biology, vol.11, issue.7, pp.502-516, 2010. ,
Monomeric alpha-catenin links cadherin to the actin cytoskeleton, Nature cell biology, vol.15, issue.3, pp.261-73, 2013. ,
Girdin-mediated interactions between cadherin and the actin cytoskeleton are required for epithelial morphogenesis in Drosophila, Development, vol.142, issue.10, pp.1777-84, 2015. ,
Girdin/GIV regulates collective cancer cell migration by controlling cell adhesion and cytoskeletal organization, Cancer Sci, 2018. ,
Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain, The Journal of neuroscience: the official journal of the Society for Neuroscience, vol.31, issue.22, pp.8109-8131, 2011. ,
Independent cadherin-catenin and Bazooka clusters interact to assemble adherens junctions, The Journal of cell biology, vol.185, issue.5, p.2711589, 2009. ,
bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila. The Journal of cell biology, vol.134, pp.149-63, 1996. ,
, , p.2120925
Integrated activity of PDZ protein complexes regulates epithelial polarity, Nature cell biology, vol.5, issue.1, pp.53-61, 2003. ,
Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila, The Journal of cell biology, vol.167, issue.1, p.2172516, 2004. ,
The Apical Polarity Protein Network in Drosophila Epithelial Cells: Regulation of Polarity, Junctions, Morphogenesis, Cell Growth, and Survival, Annu Rev Cell Dev Biol, 2012. ,
Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts, The Journal of cell biology, vol.150, issue.6, pp.1361-74, 2000. ,
The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila, The Journal of cell biology, vol.170, issue.5, p.2171335, 2005. ,
Pak1 Kinase Maintains Apical Membrane Identity in Epithelia, Cell Rep, vol.22, issue.7, p.5847184, 2018. ,
Positive feedback and mutual antagonism combine to polarize Crumbs in the Drosophila follicle cell epithelium, Current biology: CB, vol.22, issue.12, pp.1116-1138, 2012. ,
Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis, Developmental cell, vol.6, issue.6, pp.845-54, 2004. ,
Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition, Mol Cell, vol.13, issue.5, pp.86-89, 2004. ,
Formation of a Bazooka-Stardust complex is essential for plasma membrane polarity in epithelia, The Journal of cell biology, vol.190, issue.5, 2010. ,
aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells, Cell, vol.141, issue.3, pp.193-198, 2010. ,
Crumbs/DaPKC-dependent apical exclusion of Bazooka promotes photoreceptor polarity remodeling, Epub 2010/05/25, vol.20, pp.561-561, 2010. ,
Bazooka inhibits aPKC to limit antagonism of actomyosin networks during amnioserosa apical constriction, Development, vol.140, issue.23, pp.4719-4748, 2013. ,
aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization. Developmental cell, vol.38, pp.384-98, 2016. ,
, , p.4998004
Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis, Cancer Cell, vol.22, issue.5, p.3500525, 2012. ,
aPKC: the Kinase that Phosphorylates Cell Polarity, vol.7, 2018. ,
A bidirectional antagonism between aPKC and Yurt regulates epithelial cell polarity, The Journal of cell biology, vol.204, issue.4, p.3926957, 2014. ,
Oligomerization of the FERM-FA protein Yurt controls epithelial cell polarity, The Journal of cell biology, 2018. ,
Novel insights into epithelial polarity proteins in Drosophila, Trends Cell Biol, 2011. ,
The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size, Developmental cell, vol.11, issue.3, pp.257-264, 2006. ,
K(+)-ATPase form a novel group of epithelial polarity proteins, Coracle, Neurexin IV and the Na(+), vol.459, pp.1141-1146, 2009. ,
Molecular Control of Atypical Protein Kinase C: Tipping the Balance between Self-Renewal and Differentiation, J Mol Biol, vol.428, issue.7, p.4848065, 2016. ,
Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization, Nature cell biology, vol.5, issue.1, pp.46-52, 2003. ,
Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity, Journal of cell science, vol.119, pp.2107-2125, 2006. ,
DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila, The Journal of cell biology, vol.166, issue.4, p.2172211, 2004. ,
The PAR complex regulates pulsed actomyosin contractions during amnioserosa apical constriction in Drosophila, Development, vol.137, issue.10, pp.1645-55, 2010. ,
Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling, Molecular biology of the cell, vol.26, issue.20, p.4603929, 2015. ,
A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity, Nature cell biology, vol.2, issue.8, pp.540-547, 2000. ,
Involvement of Girdin in the determination of cell polarity during cell migration, PloS one, vol.7, issue.5, p.3344933, 2012. ,
The PAR proteins: fundamental players in animal cell polarization. Developmental cell, vol.13, pp.385-386, 2007. ,
Regulation of epithelial cell polarity by PAR-3 depends on Girdin transcription and Girdin-Galphai3 signaling, Journal of cell science, vol.128, issue.13, pp.2244-58, 2015. ,
AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin, Elife, vol.5, p.5119889, 2016. ,
Molecular mechanisms of de novo lumen formation, Nature reviews Molecular cell biology, vol.15, issue.10, pp.665-76, 2014. ,
Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis, The Journal of cell biology, vol.183, issue.4, p.2582895, 2008. ,
Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins, Current biology: CB, vol.20, issue.20, p.2963683, 2010. ,
AMPK regulates mitotic spindle orientation through phosphorylation of myosin regulatory light chain. Molecular and cellular biology, vol.32, p.3434549, 2012. ,
Molecular pathways regulating mitotic spindle orientation in animal cells. Development, vol.140, p.3631962, 2013. ,
Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis, The Journal of biological chemistry, vol.286, issue.14, p.3069449, 2011. ,
Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors, Genes & development, vol.18, issue.16, pp.1909-1934, 2004. ,
shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia, Genes & development, vol.10, issue.6, pp.672-85, 1996. ,
Identification of a Drosophila homologue of alpha-catenin and its association with the armadillo protein, The Journal of cell biology, vol.121, issue.5, p.2119693, 1993. ,
The product of the Drosophila segment polarity gene armadillo is part of a multi-protein complex resembling the vertebrate adherens junction, Journal of cell science, vol.105, pp.993-1000, 1993. ,
The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl, Nature, vol.422, issue.6929, pp.326-356, 2003. ,
Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs, Developmental cell, vol.35, issue.2, pp.199-210, 2015. ,
Update on Sporadic Colorectal Cancer Genetics, Clin Colon Rectal Surg, vol.31, issue.3, p.5929885, 2018. ,
Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures, The Journal of cell biology, vol.152, issue.6, p.2199212, 2001. ,
Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells, Genes Cells, vol.7, issue.11, pp.1161-71, 2002. ,
The PAR-aPKC system: lessons in polarity, Journal of cell science, vol.119, pp.979-87, 2006. ,
now, GEMs: New kids on the heterotrimeric G protein signaling block, Cell cycle, vol.16, issue.7, p.5397260, 2017. ,
Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time, Bioessays, vol.38, issue.4, p.5123561, 2016. ,
The stress polarity pathway: AMPK 'GIV'-es protection against metabolic insults, Aging (Albany NY), vol.9, issue.2, p.5361665, 2017. ,
GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling, Proceedings of the National Academy of Sciences of the United States of America, vol.106, issue.9, p.2651282, 2009. ,
Girding for migratory cues: roles of the Akt substrate Girdin in cancer progression and angiogenesis, Cancer Sci, vol.101, issue.4, pp.836-878, 2010. ,
GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation, The Journal of biological chemistry, vol.290, issue.11, p.4358093, 2015. ,
Atypical protein kinase Ciota as a human oncogene and therapeutic target, Biochem Pharmacol, vol.88, issue.1, p.3944347, 2014. ,
Expression of polarity genes in human cancer, Cancer Inform, vol.14, issue.3, p.4390136, 2015. ,
Cadherins and cancer: how does cadherin dysfunction promote tumor progression?, Oncogene, vol.27, issue.55, p.2745643, 2008. ,
Rewiring cell polarity signaling in cancer, Oncogene, vol.34, issue.8, pp.939-50, 2015. ,
Developmental capacities of benign and malignant neoplasms ofDrosophila, Wilhelm Roux Arch Entwickl Mech Org, vol.176, issue.1, pp.23-65, 1974. ,
The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster, Genetics, vol.144, issue.4, pp.1673-1682, 1996. ,