Defective mitochondrial fusion, altered respiratory function, and distorted cristae structure in skin fibroblasts with heterozygous OPA1 mutations, Biochim. Biophys. Acta BBA -Mol, pp.1570-1580, 2012. ,
The kinase Eg2 is a component of the Xenopus oocyte progesterone-activated signaling pathway, EMBO J, vol.17, pp.5627-5637, 1998. ,
Aurora Kinase Inhibitors: Current Status and Outlook, Front. Oncol, vol.5, 2015. ,
Structural basis of Aurora-A activation by TPX2 at the mitotic spindle, Mol. Cell, vol.12, pp.851-862, 2003. ,
Insights into the non-mitotic functions of Aurora kinase A: more than just cell division, Cell. Mol. Life Sci, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02304767
The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance, Autophagy, vol.9, pp.1801-1817, 2013. ,
A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells, Nat. Commun, vol.7, p.12674, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01394773
Aurora kinase A localises to mitochondria to control organelle dynamics and energy production, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01862597
Optimized FRET Pairs and Quantification Approaches To Detect the Activation of Aurora Kinase A at Mitosis, ACS Sens, vol.4, pp.2018-2027, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02280595
A guided tour into subcellular colocalization analysis in light microscopy, J. Microsc, vol.224, pp.213-232, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00132481
Characterization of the TPX2 Domains Involved in Microtubule Nucleation and Spindle Assembly in Xenopus Egg Extracts, Mol. Biol. Cell, vol.15, pp.5318-5328, 2004. ,
The D-Box-activating domain (DAD) is a new proteolysis signal that stimulates the silent D-Box sequence of Aurora-A, EMBO Rep, vol.3, pp.1209-1214, 2002. ,
URL : https://hal.archives-ouvertes.fr/inserm-00966251
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy, Hum. Mol. Genet, vol.20, pp.1726-1737, 2011. ,
Crystal Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase, J. Biol. Chem, vol.277, pp.42419-42422, 2002. ,
Skp-cullin-F box E3 ligase component FBXL2, 2013. ,
, ubiquitinates Aurora B to inhibit tumorigenesis, Cell Death Dis, vol.4, p.759
Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest, Cell Cycle Georget. Tex, vol.11, pp.721-729, 2012. ,
, , 2017.
Is a Priority Pharmaceutical Target for the Treatment of Cancers, Trends Pharmacol. Sci, vol.38, pp.687-700 ,
HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKK?, Nat. Commun, vol.9, 2018. ,
A novel mechanism for activation of the protein kinase Aurora A, Curr. Biol, vol.13, pp.691-697, 2003. ,
The potential role of Aurora kinase inhibitors in haematological malignancies: Review, Br. J. Haematol, vol.155, pp.561-579, 2011. ,
Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation, Cancer Sci, vol.97, pp.729-736, 2006. ,
PINK1/Parkinmediated mitophagy is dependent on VDAC1 and p62/SQSTM1, Nat. Cell Biol, vol.12, pp.119-131, 2010. ,
Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules, J. Cell Biol, vol.156, pp.437-451, 2002. ,
URL : https://hal.archives-ouvertes.fr/inserm-00966242
Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles, Cell, vol.81, pp.95-105, 1995. ,
Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus, Open Biol, vol.8, p.170272, 2018. ,
FBXW7/hCDC4 controls glioma cell proliferation in vitro and is a prognostic marker for survival in glioblastoma patients, Cell Div, vol.2, p.9, 2007. ,
URL : https://hal.archives-ouvertes.fr/inserm-00966662
Mechanisms of Autophagy Initiation, Annu. Rev. Biochem, vol.86, pp.225-244, 2017. ,
TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy, Autophagy, vol.9, pp.1955-1964, 2013. ,
RALA and RALBP1 regulate mitochondrial fission at mitosis, Nat. Cell Biol, vol.13, pp.1108-1115, 2011. ,
Selective degradation of mitochondria by mitophagy, Arch. Biochem. Biophys, vol.462, pp.245-253, 2007. ,
Pitchfork Regulates Primary Cilia Disassembly and Left-Right Asymmetry, Dev. Cell, vol.19, pp.66-77, 2010. ,
Guidelines for the use and interpretation of assays for monitoring autophagy, Autophagy, vol.12, pp.1-222, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-02486052
Identification of Novel Aurora Kinase A (AURKA) Inhibitors via Hierarchical Ligand-Based Virtual Screening, J. Chem. Inf. Model, vol.58, pp.36-47, 2018. ,
Mechanisms for nonmitotic activation of Aurora-A at cilia, Biochem. Soc. Trans, vol.45, pp.37-49, 2017. ,
Human TPX2 is required for targeting Aurora-A kinase to the spindle, J. Cell Biol, vol.158, pp.617-623, 2002. ,
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy, Nature, vol.524, pp.309-314, 2015. ,
, , 2006.
, Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation, Genes Dev, vol.20, pp.3464-3474
Identification of a novel Wnt5a-CK1?-Dvl2-Plk1-mediated primary cilia disassembly pathway: Primary cilia disassembly by the Dvl2-Plk1 complex, EMBO J, vol.31, pp.3104-3117, 2012. ,
Spatio-Temporal Quantification of FRET in living cells by fast time-domain FLIM: a comparative study of non-fitting methods, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00877143
, PloS One, vol.8, p.69335
Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells, Br. J. Cancer, vol.107, pp.1692-1701, 2012. ,
Ubiquitin-Mediated Degradation of Aurora Kinases, Front. Oncol, vol.5, 2016. ,
Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit, Genes Dev, vol.16, pp.2274-2285, 2002. ,
Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A, Proc. Natl. Acad. Sci. U. S. A, vol.99, pp.15440-15445, 2002. ,
Aurora kinase A inhibition and paclitaxel as targeted combination therapy for head and neck squamous cell carcinoma, Head Neck, vol.31, pp.625-634, 2009. ,
Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status, Cell Metab, vol.17, pp.719-730, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00905845
Mitochondrial degradation and energy metabolism, Biochim. Biophys. Acta BBA -Mol. Cell Res, vol.1853, pp.2812-2821, 2015. ,
A molecular perspective of mammalian autophagosome biogenesis, J. Biol. Chem, vol.293, pp.5386-5395, 2018. ,
The nephronophthisis gene product NPHP2/Inversin interacts with Aurora A and interferes with HDAC6-mediated cilia disassembly, Nephrol. Dial. Transplant, vol.28, pp.2744-2753, 2013. ,
Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria, Genes Dev, vol.22, pp.476-488, 2008. ,
Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages, Mol. Biol. Cell, vol.26, pp.4325-4332, 2015. ,
Metabolic regulation of mitochondrial dynamics, J. Cell Biol, vol.212, pp.379-387, 2016. ,
Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila, Genes Dev, vol.4, pp.1848-1861, 1990. ,
Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo, Proc. Natl. Acad. Sci, vol.107, pp.832-837, 2010. ,
Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy, Essays Biochem, vol.55, pp.39-50, 2013. ,
, , 2008.
, Parkin is recruited selectively to impaired mitochondria and promotes their autophagy, J. Cell Biol, vol.183, pp.795-803
Aurora A kinase (AURKA) in normal and pathological cell division, Cell. Mol. Life Sci, vol.70, pp.661-687, 2013. ,
Nix is a selective autophagy receptor for mitochondrial clearance, EMBO Rep, vol.11, pp.45-51, 2010. ,
Quantitative FRET analysis by fast acquisition time domain FLIM at high spatial resolution in living cells, Biophys. J, vol.95, pp.2976-2988, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00289731
Poly(A) metabolism and polysomal recruitment of maternal mRNAs during early Xenopus development, Dev. Biol, vol.140, pp.221-224, 1990. ,
Prediction of kinase-specific phosphorylation sites through an integrative model of protein context and sequence, Biochim. Biophys. Acta, vol.1864, pp.1599-1608, 2016. ,
The Roles of PINK1, Parkin and Mitochondrial Fidelity in Parkinson's Disease, Neuron, vol.85, pp.257-273, 2015. ,
NIPSNAP1 and NIPSNAP2 Act as, Eat Me" Signals for Mitophagy. Dev. Cell, vol.49, pp.509-525, 2019. ,
The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome, Nat. Cell Biol, vol.7, pp.937-946, 2005. ,
HEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium, Cell, vol.129, pp.1351-1363, 2007. ,
The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly, J. Cell Sci, vol.111, pp.557-572, 1998. ,
URL : https://hal.archives-ouvertes.fr/inserm-00966036
Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein, ACS Chem. Biol, vol.7, pp.892-900, 2012. ,
Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy, Autophagy, vol.5, pp.690-698, 2009. ,
The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas: Alisertib & Docetaxel Inhibit Tumor Growth, Cancer, vol.119, pp.904-914, 2013. ,
Automated screening of AURKA activity based on a genetically encoded FRET biosensor using fluorescence lifetime imaging microscopy, Methods Appl. Fluoresc, vol.8, p.24006, 2020. ,
URL : https://hal.archives-ouvertes.fr/hal-02500623
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD, Autophagy, vol.6, pp.217-227, 2010. ,
The Non-Canonical Role of Aurora-A in DNA Replication, Front. Oncol, vol.5, 2015. ,
The Interplay Between Mitochondrial Dynamics and Mitophagy, Antioxid. Redox Signal, vol.14, pp.1939-1951, 2011. ,
Size matters! Aurora A controls Drosophila larval development, Dev. Biol, vol.440, pp.88-98, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01812516
No Parkin Zone: Mitophagy without Parkin, Trends Cell Biol, 2018. ,
The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation, Oncogene, vol.19, pp.4906-4916, 2000. ,
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts, Genes Dev, vol.20, pp.3453-3463, 2006. ,
Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor, Cell, vol.168, pp.224-238, 2017. ,
Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization, Cell, vol.135, pp.161-173, 2008. ,
STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism, Nat. Commun, vol.10, 2019. ,
GPS: a comprehensive www server for phosphorylation sites prediction, Nucleic Acids Res, vol.33, pp.184-187, 2005. ,
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis, pp.1-16, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02361056
, , 2011.
, Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane?, J. Biol. Chem, vol.286, pp.19630-19640
, , 2015.
, Xanthohumol suppresses oestrogen-signalling in breast cancer through the inhibition of BIG3-PHB2 interactions, p.7355
Mechanisms of mitophagy, Nat. Rev. Mol. Cell Biol, vol.12, pp.9-14, 2011. ,
Chfr is required for tumor suppression and Aurora A regulation, Nat. Genet, vol.37, pp.401-406, 2005. ,
Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation, Blood, vol.114, pp.157-164, 2009. ,
Identification of the auto-inhibitory domains of Aurora-A kinase, Biochem. Biophys. Res. Commun, vol.357, pp.347-352, 2007. ,
Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype, Nat. Commun, vol.7, p.10180, 2016. ,