V. Agier, P. Oliviero, J. Lainé, C. L'hermitte-stead, S. Girard et al., Defective mitochondrial fusion, altered respiratory function, and distorted cristae structure in skin fibroblasts with heterozygous OPA1 mutations, Biochim. Biophys. Acta BBA -Mol, pp.1570-1580, 2012.

T. Andrésson and J. V. Ruderman, The kinase Eg2 is a component of the Xenopus oocyte progesterone-activated signaling pathway, EMBO J, vol.17, pp.5627-5637, 1998.

V. Bavetsias and S. Linardopoulos, Aurora Kinase Inhibitors: Current Status and Outlook, Front. Oncol, vol.5, 2015.

R. Bayliss, T. Sardon, I. Vernos, and E. Conti, Structural basis of Aurora-A activation by TPX2 at the mitotic spindle, Mol. Cell, vol.12, pp.851-862, 2003.

G. Bertolin and M. Tramier, Insights into the non-mitotic functions of Aurora kinase A: more than just cell division, Cell. Mol. Life Sci, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02304767

G. Bertolin, R. Ferrando-miguel, M. Jacoupy, S. Traver, K. Grenier et al., The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance, Autophagy, vol.9, pp.1801-1817, 2013.

G. Bertolin, F. Sizaire, G. Herbomel, D. Reboutier, C. Prigent et al., A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells, Nat. Commun, vol.7, p.12674, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01394773

G. Bertolin, A. Bulteau, M. Alves-guerra, A. Burel, M. Lavault et al., Aurora kinase A localises to mitochondria to control organelle dynamics and energy production, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01862597

G. Bertolin, F. Sizaire, C. Déméautis, C. Chapuis, F. Mérola et al., Optimized FRET Pairs and Quantification Approaches To Detect the Activation of Aurora Kinase A at Mitosis, ACS Sens, vol.4, pp.2018-2027, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02280595

S. Bolte and F. P. Cordelieres, A guided tour into subcellular colocalization analysis in light microscopy, J. Microsc, vol.224, pp.213-232, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00132481

S. Brunet, T. Sardon, T. Zimmerman, T. Wittmann, R. Pepperkok et al., Characterization of the TPX2 Domains Involved in Microtubule Nucleation and Spindle Assembly in Xenopus Egg Extracts, Mol. Biol. Cell, vol.15, pp.5318-5328, 2004.

A. Castro, S. Vigneron, C. Bernis, J. Labbé, C. Prigent et al., The D-Box-activating domain (DAD) is a new proteolysis signal that stimulates the silent D-Box sequence of Aurora-A, EMBO Rep, vol.3, pp.1209-1214, 2002.
URL : https://hal.archives-ouvertes.fr/inserm-00966251

N. C. Chan, A. M. Salazar, A. H. Pham, M. J. Sweredoski, N. J. Kolawa et al., Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy, Hum. Mol. Genet, vol.20, pp.1726-1737, 2011.

G. M. Cheetham, Crystal Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase, J. Biol. Chem, vol.277, pp.42419-42422, 2002.

B. B. Chen, J. R. Glasser, T. A. Coon, and R. K. Mallampalli, Skp-cullin-F box E3 ligase component FBXL2, 2013.

, ubiquitinates Aurora B to inhibit tumorigenesis, Cell Death Dis, vol.4, p.759

T. A. Coon, J. R. Glasser, R. K. Mallampalli, C. , and B. B. , Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest, Cell Cycle Georget. Tex, vol.11, pp.721-729, 2012.

A. P. Damodaran, L. Vaufrey, O. Gavard, and C. Prigent, , 2017.

A. Aurora and . Kinase, Is a Priority Pharmaceutical Target for the Treatment of Cancers, Trends Pharmacol. Sci, vol.38, pp.687-700

A. Di-rita, A. Peschiaroli, P. D?acunzo, D. Strobbe, Z. Hu et al., HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKK?, Nat. Commun, vol.9, 2018.

P. A. Eyers, E. Erikson, L. G. Chen, and J. L. Maller, A novel mechanism for activation of the protein kinase Aurora A, Curr. Biol, vol.13, pp.691-697, 2003.

S. S. Farag, The potential role of Aurora kinase inhibitors in haematological malignancies: Review, Br. J. Haematol, vol.155, pp.561-579, 2011.

Y. Fujii, M. Yada, M. Nishiyama, T. Kamura, H. Takahashi et al., Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation, Cancer Sci, vol.97, pp.729-736, 2006.

S. Geisler, K. M. Holmström, D. Skujat, F. C. Fiesel, O. C. Rothfuss et al., PINK1/Parkinmediated mitophagy is dependent on VDAC1 and p62/SQSTM1, Nat. Cell Biol, vol.12, pp.119-131, 2010.

R. Giet, D. Mclean, S. Descamps, M. J. Lee, J. W. Raff et al., Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules, J. Cell Biol, vol.156, pp.437-451, 2002.
URL : https://hal.archives-ouvertes.fr/inserm-00966242

D. M. Glover, M. H. Leibowitz, D. A. Mclean, and H. Parry, Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles, Cell, vol.81, pp.95-105, 1995.

R. Grant, A. Abdelbaki, A. Bertoldi, M. P. Gavilan, J. Mansfeld et al., Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus, Open Biol, vol.8, p.170272, 2018.

M. Hagedorn, M. Delugin, I. Abraldes, N. Allain, M. Belaud-rotureau et al., FBXW7/hCDC4 controls glioma cell proliferation in vitro and is a prognostic marker for survival in glioblastoma patients, Cell Div, vol.2, p.9, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00966662

J. H. Hurley and L. N. Young, Mechanisms of Autophagy Initiation, Annu. Rev. Biochem, vol.86, pp.225-244, 2017.

P. Isakson, A. H. Lystad, K. Breen, G. Koster, H. Stenmark et al., TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy, Autophagy, vol.9, pp.1955-1964, 2013.

D. F. Kashatus, K. Lim, D. C. Brady, N. L. Pershing, A. D. Cox et al., RALA and RALBP1 regulate mitochondrial fission at mitosis, Nat. Cell Biol, vol.13, pp.1108-1115, 2011.

I. Kim, S. Rodriguez-enriquez, and J. J. Lemasters, Selective degradation of mitochondria by mitophagy, Arch. Biochem. Biophys, vol.462, pp.245-253, 2007.

D. Kinzel, K. Boldt, E. E. Davis, I. Burtscher, D. Trümbach et al., Pitchfork Regulates Primary Cilia Disassembly and Left-Right Asymmetry, Dev. Cell, vol.19, pp.66-77, 2010.

D. J. Klionsky, K. Abdelmohsen, A. Abe, M. J. Abedin, H. Abeliovich et al., Guidelines for the use and interpretation of assays for monitoring autophagy, Autophagy, vol.12, pp.1-222, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02486052

Y. Kong, A. Bender, Y. , and A. , Identification of Novel Aurora Kinase A (AURKA) Inhibitors via Hierarchical Ligand-Based Virtual Screening, J. Chem. Inf. Model, vol.58, pp.36-47, 2018.

V. Korobeynikov, A. Y. Deneka, and E. A. Golemis, Mechanisms for nonmitotic activation of Aurora-A at cilia, Biochem. Soc. Trans, vol.45, pp.37-49, 2017.

T. A. Kufer, H. H. Silljé, R. Körner, O. J. Gruss, P. Meraldi et al., Human TPX2 is required for targeting Aurora-A kinase to the spindle, J. Cell Biol, vol.158, pp.617-623, 2002.

M. Lazarou, D. A. Sliter, L. A. Kane, S. A. Sarraf, C. Wang et al., The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy, Nature, vol.524, pp.309-314, 2015.

C. Lee, R. O. Andersen, C. Cabernard, L. Manning, K. D. Tran et al., , 2006.

, Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation, Genes Dev, vol.20, pp.3464-3474

K. H. Lee, Y. Johmura, L. Yu, J. Park, Y. Gao et al., Identification of a novel Wnt5a-CK1?-Dvl2-Plk1-mediated primary cilia disassembly pathway: Primary cilia disassembly by the Dvl2-Plk1 complex, EMBO J, vol.31, pp.3104-3117, 2012.

A. Leray, S. Padilla-parra, J. Roul, L. Héliot, and M. Tramier, Spatio-Temporal Quantification of FRET in living cells by fast time-domain FLIM: a comparative study of non-fitting methods, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00877143

, PloS One, vol.8, p.69335

Y. Lin, F. M. Richards, B. Krippendorff, J. L. Bramhall, J. A. Harrington et al., Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells, Br. J. Cancer, vol.107, pp.1692-1701, 2012.

C. Lindon, R. Grant, M. , and M. , Ubiquitin-Mediated Degradation of Aurora Kinases, Front. Oncol, vol.5, 2016.

L. E. Littlepage and J. V. Ruderman, Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit, Genes Dev, vol.16, pp.2274-2285, 2002.

L. E. Littlepage, H. Wu, T. Andresson, J. K. Deanehan, L. T. Amundadottir et al., Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A, Proc. Natl. Acad. Sci. U. S. A, vol.99, pp.15440-15445, 2002.

A. Mazumdar, Y. C. Henderson, A. K. El-naggar, S. Sen, and G. L. Clayman, Aurora kinase A inhibition and paclitaxel as targeted combination therapy for head and neck squamous cell carcinoma, Head Neck, vol.31, pp.625-634, 2009.

S. Melser, E. H. Chatelain, J. Lavie, W. Mahfouf, C. Jose et al., Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status, Cell Metab, vol.17, pp.719-730, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00905845

S. Melser, J. Lavie, and G. Bénard, Mitochondrial degradation and energy metabolism, Biochim. Biophys. Acta BBA -Mol. Cell Res, vol.1853, pp.2812-2821, 2015.

T. J. Mercer, A. Gubas, and S. A. Tooze, A molecular perspective of mammalian autophagosome biogenesis, J. Biol. Chem, vol.293, pp.5386-5395, 2018.

M. Mergen, C. Engel, B. Muller, M. Follo, T. Schafer et al., The nephronophthisis gene product NPHP2/Inversin interacts with Aurora A and interferes with HDAC6-mediated cilia disassembly, Nephrol. Dial. Transplant, vol.28, pp.2744-2753, 2013.

C. Merkwirth, S. Dargazanli, T. Tatsuta, S. Geimer, B. Löwer et al., Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria, Genes Dev, vol.22, pp.476-488, 2008.

M. Min, T. E. Mevissen, M. De-luca, D. Komander, and C. Lindon, Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages, Mol. Biol. Cell, vol.26, pp.4325-4332, 2015.

P. Mishra, C. , and D. C. , Metabolic regulation of mitochondrial dynamics, J. Cell Biol, vol.212, pp.379-387, 2016.

M. Mlodzik, N. E. Baker, and G. M. Rubin, Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila, Genes Dev, vol.4, pp.1848-1861, 1990.

M. Mortensen, D. J. Ferguson, M. Edelmann, B. Kessler, K. J. Morten et al., Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo, Proc. Natl. Acad. Sci, vol.107, pp.832-837, 2010.

H. Nakatogawa, Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy, Essays Biochem, vol.55, pp.39-50, 2013.

D. Narendra, A. Tanaka, D. Suen, Y. , and R. J. , , 2008.

, Parkin is recruited selectively to impaired mitochondria and promotes their autophagy, J. Cell Biol, vol.183, pp.795-803

A. S. Nikonova, I. Astsaturov, I. G. Serebriiskii, R. L. Dunbrack, and E. A. Golemis, Aurora A kinase (AURKA) in normal and pathological cell division, Cell. Mol. Life Sci, vol.70, pp.661-687, 2013.

I. Novak, V. Kirkin, D. G. Mcewan, J. Zhang, P. Wild et al., Nix is a selective autophagy receptor for mitochondrial clearance, EMBO Rep, vol.11, pp.45-51, 2010.

S. Padilla-parra, N. Audugé, M. Coppey-moisan, and M. Tramier, Quantitative FRET analysis by fast acquisition time domain FLIM at high spatial resolution in living cells, Biophys. J, vol.95, pp.2976-2988, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00289731

J. Paris, P. , and M. , Poly(A) metabolism and polysomal recruitment of maternal mRNAs during early Xenopus development, Dev. Biol, vol.140, pp.221-224, 1990.

R. Patrick, C. Horin, B. Kobe, K. L. Cao, and M. Bodén, Prediction of kinase-specific phosphorylation sites through an integrative model of protein context and sequence, Biochim. Biophys. Acta, vol.1864, pp.1599-1608, 2016.

A. M. Pickrell, Y. , and R. J. , The Roles of PINK1, Parkin and Mitochondrial Fidelity in Parkinson's Disease, Neuron, vol.85, pp.257-273, 2015.

Y. Princely-abudu, S. Pankiv, B. J. Mathai, A. Håkon-lystad, C. Bindesbøll et al., NIPSNAP1 and NIPSNAP2 Act as, Eat Me" Signals for Mitophagy. Dev. Cell, vol.49, pp.509-525, 2019.

E. N. Pugacheva and E. A. Golemis, The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome, Nat. Cell Biol, vol.7, pp.937-946, 2005.

E. N. Pugacheva, S. A. Jablonski, T. R. Hartman, E. P. Henske, and E. A. Golemis, HEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium, Cell, vol.129, pp.1351-1363, 2007.

C. Roghi, R. Giet, R. Uzbekov, N. Morin, I. Chartrain et al., The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly, J. Cell Sci, vol.111, pp.557-572, 1998.
URL : https://hal.archives-ouvertes.fr/inserm-00966036

Y. Sasazawa, S. Kanagaki, E. Tashiro, T. Nogawa, M. Muroi et al., Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein, ACS Chem. Biol, vol.7, pp.892-900, 2012.

M. Schwarten, J. Mohrlüder, P. Ma, M. Stoldt, Y. Thielmann et al., Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy, Autophagy, vol.5, pp.690-698, 2009.

V. Sehdev, A. Katsha, J. Ecsedy, A. Zaika, A. Belkhiri et al., The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas: Alisertib & Docetaxel Inhibit Tumor Growth, Cancer, vol.119, pp.904-914, 2013.

F. Sizaire, G. Le-marchand, J. Pécréaux, O. Bouchareb, and M. Tramier, Automated screening of AURKA activity based on a genetically encoded FRET biosensor using fluorescence lifetime imaging microscopy, Methods Appl. Fluoresc, vol.8, p.24006, 2020.
URL : https://hal.archives-ouvertes.fr/hal-02500623

E. Tresse, F. A. Salomons, J. Vesa, L. C. Bott, V. Kimonis et al., VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD, Autophagy, vol.6, pp.217-227, 2010.

T. Tsunematsu, R. Arakaki, A. Yamada, N. Ishimaru, and Y. Kudo, The Non-Canonical Role of Aurora-A in DNA Replication, Front. Oncol, vol.5, 2015.

G. Twig and O. S. Shirihai, The Interplay Between Mitochondrial Dynamics and Mitophagy, Antioxid. Redox Signal, vol.14, pp.1939-1951, 2011.

L. Vaufrey, C. Balducci, R. Lafont, C. Prigent, L. Bras et al., Size matters! Aurora A controls Drosophila larval development, Dev. Biol, vol.440, pp.88-98, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01812516

E. Villa, S. Marchetti, and J. Ricci, No Parkin Zone: Mitophagy without Parkin, Trends Cell Biol, 2018.

A. O. Walter, W. Seghezzi, W. Korver, J. Sheung, and E. Lees, The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation, Oncogene, vol.19, pp.4906-4916, 2000.

H. Wang, G. W. Somers, A. Bashirullah, U. Heberlein, F. Yu et al., Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts, Genes Dev, vol.20, pp.3453-3463, 2006.

Y. Wei, W. Chiang, R. Sumpter, P. Mishra, and B. Levine, Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor, Cell, vol.168, pp.224-238, 2017.

F. Wirtz-peitz, T. Nishimura, and J. A. Knoblich, Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization, Cell, vol.135, pp.161-173, 2008.

H. Xian, Q. Yang, L. Xiao, H. Shen, and Y. Liou, STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism, Nat. Commun, vol.10, 2019.

Y. Xue, F. Zhou, M. Zhu, K. Ahmed, G. Chen et al., GPS: a comprehensive www server for phosphorylation sites prediction, Nucleic Acids Res, vol.33, pp.184-187, 2005.

C. Yan, L. Gong, L. Chen, M. Xu, H. Abou-hamdan et al., PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis, pp.1-16, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02361056

S. R. Yoshii, C. Kishi, N. Ishihara, and N. Mizushima, , 2011.

, Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane?, J. Biol. Chem, vol.286, pp.19630-19640

T. Yoshimaru, M. Komatsu, E. Tashiro, M. Imoto, H. Osada et al., , 2015.

, Xanthohumol suppresses oestrogen-signalling in breast cancer through the inhibition of BIG3-PHB2 interactions, p.7355

R. J. Youle and D. P. Narendra, Mechanisms of mitophagy, Nat. Rev. Mol. Cell Biol, vol.12, pp.9-14, 2011.

X. Yu, K. Minter-dykhouse, L. Malureanu, W. Zhao, D. Zhang et al., Chfr is required for tumor suppression and Aurora A regulation, Nat. Genet, vol.37, pp.401-406, 2005.

J. Zhang, M. S. Randall, M. R. Loyd, F. C. Dorsey, M. Kundu et al., Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation, Blood, vol.114, pp.157-164, 2009.

Y. Zhang, J. Ni, Q. Huang, W. Ren, L. Yu et al., Identification of the auto-inhibitory domains of Aurora-A kinase, Biochem. Biophys. Res. Commun, vol.357, pp.347-352, 2007.

F. Zheng, C. Yue, G. Li, B. He, W. Cheng et al., Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype, Nat. Commun, vol.7, p.10180, 2016.