Synthesis of halogenated 1-O-alkylglycerols from ricinoleic acid derivatives

René Pemha; Dieudonne Emmanuel Pegnyemb; Paul Mosset

doi:10.1080/00397911.2020.1750034

Journal articles

Synthesis of halogenated 1-O-alkylglycerols from ricinoleic acid derivatives

René Pemha ^{1, 2, *} Dieudonne Emmanuel Pegnyemb ³ Paul Mosset ¹

* Corresponding author

1 ISCR - Institut des Sciences Chimiques de Rennes

2 UPJV EA4294 - AGIR - Agents infectieux, résistance et chimiothérapie

3 University of Yaounde I - National Advanced School of Engineering

Abstract : Resistance to the existing drugs and increasing numbers of diseases result in identifying new drug candidates with new forms of activity. As marine organisms are well known to provide a wide range of original compounds, Herein, we report the synthesis of new non-natural brominated, iodinated and chlorinated-substituted 1-O-alkylglycerols 5-7, analogs of a prominent 1-O-alkylglycerol (AKG) of the natural shark liver oil (SLO) mixture, namely the AKGs 181, n-9.

Keywords : Alkylglycerol (AKG) fatty acids halogenated compounds lipids marine natural products

Document type :

Journal articles

Domain :

Chemical Sciences

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https://hal-univ-rennes1.archives-ouvertes.fr/hal-02634589
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Submitted on : Wednesday, May 27, 2020 - 3:46:43 PM
Last modification on : Tuesday, January 19, 2021 - 11:02:11 AM

Synthesis of halogenated 1-O-alkylglycerols from ricinoleic acid derivatives

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Synthesis of halogenated 1-O-alkylglycerols from ricinoleic acid derivatives

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