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Synthesis of halogenated 1-O-alkylglycerols from ricinoleic acid derivatives

Abstract : Resistance to the existing drugs and increasing numbers of diseases result in identifying new drug candidates with new forms of activity. As marine organisms are well known to provide a wide range of original compounds, Herein, we report the synthesis of new non-natural brominated, iodinated and chlorinated-substituted 1-O-alkylglycerols 5-7, analogs of a prominent 1-O-alkylglycerol (AKG) of the natural shark liver oil (SLO) mixture, namely the AKGs 181, n-9.
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Submitted on : Wednesday, May 27, 2020 - 3:46:43 PM
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René Pemha, Dieudonne Emmanuel Pegnyemb, Paul Mosset. Synthesis of halogenated 1-O-alkylglycerols from ricinoleic acid derivatives. Synthetic Communications, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 2020, 50 (11), pp.1656-1664. ⟨10.1080/00397911.2020.1750034⟩. ⟨hal-02634589⟩



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