Synthesis of halogenated 1-O-alkylglycerols from ricinoleic acid derivatives

René Momha (1, 2) , Dieudonne Emmanuel Pegnyemb (3) , Paul Mosset (1)

1 ISCR - Institut des Sciences Chimiques de Rennes
2 AGIR - Agents infectieux, résistance et chimiothérapie - UR UPJV 4294
3 University of Yaounde I - National Advanced School of Engineering

Resistance to the existing drugs and increasing numbers of diseases result in identifying new drug candidates with new forms of activity. As marine organisms are well known to provide a wide range of original compounds, Herein, we report the synthesis of new non-natural brominated, iodinated and chlorinated-substituted 1-O-alkylglycerols 5-7, analogs of a prominent 1-O-alkylglycerol (AKG) of the natural shark liver oil (SLO) mixture, namely the AKGs 181, n-9.

Mots clés: Alkylglycerol (AKG); fatty acids; halogenated compounds; lipids; marine natural products

Domaines: Chimie

René Momha, Dieudonne Emmanuel Pegnyemb, Paul Mosset. Synthesis of halogenated 1-O-alkylglycerols from ricinoleic acid derivatives. Synthetic Communications, 2020, 50 (11), pp.1656-1664. ⟨10.1080/00397911.2020.1750034⟩. ⟨hal-02634589⟩