Synthesis of S-mono-and S,O-bis-1,2,3-triazole linked 1,5-benzodiazepine conjugates and evaluation of their cytotoxic, anti-tyrosinase, and anti-cholinesterase activities. Phosphorus, Sulfur Silicon Relat. Elem, vol.192, pp.835-844, 2017. ,
Cardioprotective effect of resveratrol analogue isorhapontigenin versus omega-3 fatty acids in isoproterenol-induced myocardial infarction in rats, J. Physiol. Biochem, vol.72, pp.469-484, 2016. ,
Pharmacological potential of tocotrienols: A review, Nutrition Metabol, vol.11, pp.52-74, 2014. ,
Protective effect of n-3 polyunsaturated fatty acids concentrate on isoproterenol induced myocardial infarction in rats, 2007. ,
, Prostaglandins Leukot Essent. Fatty Acids, vol.76, pp.153-158
Paradoxical effects of atorvastatin in isoproterenol-induced cardiotoxicity in rats: Role of oxidative stress and inflammation, 2018. ,
, Biomedicine & Pharmacotherapy, vol.104, pp.542-549
Heart disease and stroke statistics 2017 up-date: a report from the, American Heart Association. Circulation, vol.135, issue.10, pp.146-603, 2017. ,
Combination of docking, molecular dynamics and quantum mechanical calculations for metabolism prediction of 3,4-methylenedioxybenzoyl-2-thienylhydrazone, J Mol Model, vol.18, pp.2065-2078, 2012. ,
Transforming growth factor ? in tissue fibrosis, New Eng. J. Med, vol.331, pp.1286-1292, 1994. ,
Effects of early angiotensinconverting enzyme inhibition in patients with non-ST-elevation acute anterior myocardial infarction, Amer. Heart J, vol.152, pp.470-477, 2006. ,
Design, synthesis and biological evaluation of novel 1,2,3-triazole linked coumarinopyrazole conjugates as potent anti-cholinesterase, anti-5-lipoxygenase, anti-tyrosinase and anti-cancer agents, Bioorg. Chem, vol.80, pp.189-194, 2018. ,
Design, synthesis, and anti-tumor activities of novel triphenylethylene-coumarin hybrids, and their interactions with Ct-DNA, Bioorg. Med. Chem. Lett, vol.23, pp.4785-4789, 2013. ,
Antiplatelet and Antithrombotic Activities of non-steroidal anti-inflammatory drugs containing an N-acyl hydrazone subunit, Molecules, vol.19, pp.2089-2099, 2014. ,
Rapid physiological coagulation method in determination of fibrinogen, Acta Haematol, vol.17, pp.237-246, 1957. ,
Synthesis of 3-(imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one derivatives and study of their antiviral activity against parvovirus B19, Molecules, vol.24, pp.1037-1052, 2019. ,
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis, J Am. Med. Asso, vol.294, pp.1799-1809, 2005. ,
Cardiopreventive effect of ethanolic extract of Date Palm Pollen against isoproterenol induced myocardial infarction in rats through the inhibition of the angiotensin-converting enzyme, Exp. Toxicol. Pathol, vol.69, pp.656-665, 2017. ,
Determination of fibrinogen by the Von Clauss coagulation micromethod, Pathol Biol, vol.8, pp.1615-1621, 1960. ,
Synthesis of 1,5-benzodiazepine derivatives containing 1,2,3-triazole moiety via 1,3-dipolar cycloaddition reaction, J. Hetero. Chem, vol.51, pp.1844-1848, 2014. ,
Tautomerism and conformational isomerism of mercaptoacetylhydrazones of aliphatic and aromatic aldehydes, Russ. J. Org. Chem, vol.45, pp.660-661, 2009. ,
Antifungal activity, mode of action variability, and subcellular distribution of coumarinbased antifungal azoles, Eur. J. Med. Chem, vol.179, pp.779-790, 2019. ,
Natural and synthetic coumarin derivatives with anti-inflammatory/antioxidant activities, Current Pharm. Design, vol.10, pp.3813-3833, 2014. ,
Synthesis, cytotoxic, anti-lipoxygenase and anti-acetylcholinesterase capacities of novel derivatives from harmine, J. Enz. Inhib. Med. Chem, vol.31, pp.23-33, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-02195504
In vitro and in vivo experimental model-based approaches for investigating anti-inflammatory properties of coumarins 25, pp.1446-1476, 2018. ,
Cardioprotective effects of (E)-4-hydroxy-N?-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide: a newly synthesized coumarin hydrazone against isoproterenol-induced myocardial infarction in a rat model, Can. J. Physiol. Pharmacol, vol.97, pp.989-998, 2019. ,
Hydrogen bonding in 2-nitrobenzaldehyde hydrazones and a three-dimensional hydrogen-bonded framework in 3-nitrobenzaldehyde hydrazone, Acta Crysta Sect C: Cryst. Struct. Commun, vol.60, pp.686-689, 2004. ,
Crystal structures of 1-aryl-1H-and 2-aryl-2H-1,2,3-triazolyl hydrazones, conformational consequences of different classical hydrogen bonds, J. Braz. Chem. Soc, vol.27, pp.2322-2333, 2016. ,
Coumarin: A Privileged scaffold for the design and development of antineurodegenerative agents, Chem. Biol. Drug Design, vol.87, pp.21-38, 2016. ,
Recent progress in the drug development of coumarin derivatives as potent antituberculosis agents, Eur. J. Med. Chem, vol.100, pp.257-269, 2015. ,
Amelioration of isoproterenol-induced oxidative damage in rat myocardium by Withania somnifera leaf extract, 2015. ,
, Biomed Res. Internat. Article ID, vol.624159
Renin inhibition by aliskiren protects rats against isoproterenol induced myocardial infarction, Drug Res (Stuttg), vol.68, pp.139-145, 2018. ,
Natural and synthetic coumarins with effects on inflammation, Molecules, vol.21, pp.1322-1335, 2016. ,
Studies on the antiplatelet and antithrombotic profile of anti-inflammatory coumarin derivatives, Journal of Enzyme Inhibition and Medicinal Chemistry, vol.30, pp.925-933, 2015. ,
Catalyst-free synthesis of pyrazole-aniline linked coumarin derivatives and their antimicrobial evaluation, J. Saudi Chem. Soc, vol.22, pp.665-677, 2018. ,
Synthetic and natural coumarins as cytotoxic agents, Curr. Med. Chem. Anticancer Agents, vol.5, pp.29-46, 2005. ,
Condensation von malonsäure mit aromatischen aldehyden durch ammoniak und amine, Chem. Ber, vol.31, pp.2596-2619, 1898. ,
, , 2012.
, Eur. J. Med. Chem, vol.55, pp.49-57
Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice, Blood, vol.117, pp.4953-4963, 2011. ,
Preventive effects of oleuropein against cardiac remodeling after cardiac infarction in Wistar rat through inhibiting angiotensin-converting enzyme activity, Toxicol. Mech. Methods, vol.25, pp.538-546, 2015. ,
Protective effect of hydroxytyrosol against cardiac remodeling after isoproterenol-induced myocardial infarction in rat, Cardiovascul. Toxicol, vol.16, pp.147-155, 2016. ,
Anti-embolic and anti-oxidative effects of a novel (E)-4-amino-N?-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide against isoproterenol and vitamin-K induced ischemic stroke, Archiv. Physiol. Biochem, pp.1-14, 2019. ,
Tale of coronary artery disease and myocardial infarction, New Eng. J. Med, vol.366, pp.54-63, 2012. ,
Antihyperlipidemic effect of coumarin in experimental type 2 diabetic rats, Biomed. Prevent. Nutri, vol.4, pp.171-176, 2014. ,
Protective effects of ethanolic peel and pulp extracts of Citrus macroptera fruit against isoproterenol-induced myocardial infarction in rats, Biomed. Pharmacother, vol.94, pp.256-264, 2017. ,
Synthesis, antioxidant and anti-inflammatory properties of an apocynin-derived dihydrocoumarin, Mini Rev. Med. Chem, vol.13, pp.93-100, 2017. ,
Synthesis and conformational assignment of N-(E)-stilbenyloxymethylenecarbonyl-substituted hydrazones of acetone and ortho-, meta-and para-chloro-(nitro-)benzaldehydes by means of and NMR spectroscopy, J. Spectroscopy, pp.1-12, 2013. ,
Synthesis and antioxidant study of new polyphenolic hybrid-coumarins, Arabian J. Chem, vol.11, pp.525-537, 2018. ,
New insights into highly potent tyrosinase inhibitors based on 3-heteroarylcoumarins: Anti-melanogenesis and antioxidant activities, and computational molecular modeling studies, Bioorg. Med. Chem, vol.25, pp.1687-1695, 2017. ,
Rapid molecular detection of salmonella typhi and salmonella paratyphi by polymerase chain reaction, Asian J. Microbiol. Biotechnol. Environ. Sci, vol.9, pp.675-677, 2014. ,
Coal-biomass co-combustion: An overview, Renew. Sustain. Energy Rev, vol.39, pp.575-586, 2014. ,
Cardioprotective activity of Amaranthus viridis Linn: effect on serum marker enzymes, cardiac troponin and antioxidant system in experimental myocardial infarcted rats, Internat. J. Cardiol, vol.165, pp.494-498, 2013. ,
?-Adrenoreceptor agonist Isoproterenol alters oxidative status, inflammatory signaling, injury markers and apoptotic cell death in myocardium of rats, Indian J. Clinical Biochem, vol.30, pp.27-34, 2015. ,
A review on pharmacological properties of coumarins, Mini Rev. Med. Chem, vol.18, pp.113-141, 2018. ,
Sharpe, left ventricular remodeling after myocardial infarction, Pathophysiol. Ther, vol.101, pp.2981-2988, 2000. ,
NMR study of conformation and isomerization of aryl-and hetero arylaldehyde 4-tert butylphenoxyacetylhydrazones, J. Mol. Struct, vol.788, pp.55-62, 2006. ,
Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol, Clin. Pharmacokin, vol.44, pp.1227-1246, 2005. ,
, World Health Organization (WHO) Fact sheet N°290, World Health Statistics, 2011.
Improved method for direct high-performance liquid chromatography assay of angiotensin-converting enzyme-catalyzed reactions, J. Chromato, vol.950, pp.125-130, 2002. ,
, Values are given as mean ± standard deviation / S.D. for groups of 6 animals each. The values are statistically presented as follows: a P < 0
, 05 significant difference compared to treated rats with isoprotenol (Isop)
, ? Synthesis of new (E)-N'
, ? In vitro tests showed potent inhibition of angiotensine I-converting enzyme (ACE)
, pre-treatment with 1c improved the ECG pattern ? 1c reduced the cardiac dysfunction markers and ameliorated the thrombolytic process, ? In vivo assays (on rats)