Asymmetric transfer hydrogenation of ketones promoted by manganese(I) pre-catalysts supported by bidentate aminophosphines

K. Azouzi; Antoine Bruneau-Voisine; L. Vendier; Jean-Baptiste Sortais; S. Bastin

doi:10.1016/j.catcom.2020.106040

Journal articles

Asymmetric transfer hydrogenation of ketones promoted by manganese(I) pre-catalysts supported by bidentate aminophosphines

K. Azouzi ¹ Antoine Bruneau-Voisine ² L. Vendier ¹ Jean-Baptiste Sortais ¹ S. Bastin ¹

1 LCC - Laboratoire de chimie de coordination

2 ISCR - Institut des Sciences Chimiques de Rennes

Abstract : A series of commercially available chiral amino-phosphines, in combination with Mn(CO)5Br, has been evaluated for the asymmetric reduction of ketones, using isopropanol as hydrogen source. With the most selective ligand, the corresponding manganese complex was synthesized and fully characterized. A series of ketones (20 examples) was hydrogenated in the presence of 0.5 mol% of the manganese pre-catalyst at 30 °C, affording the chiral alcohols in high yields with enantiomeric excesses up to 99%.

Keywords : Chiral aminophosphine ligands Ketones Manganese Reduction Transfer hydrogenation

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Journal articles

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Chemical Sciences / Catalysis

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Submitted on : Thursday, May 28, 2020 - 3:26:28 PM
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Asymmetric transfer hydrogenation of ketones promoted by manganese(I) pre-catalysts supported by bidentate aminophosphines

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Asymmetric transfer hydrogenation of ketones promoted by manganese(I) pre-catalysts supported by bidentate aminophosphines

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