Skip to Main content Skip to Navigation
Journal articles

Loss of SMARCB1 expression in colon carcinoma

Abstract : SMARCB1 is a tumor suppressor gene, which is part of SWI/SNF complex involved in transcriptional regulation. Recently, loss of SMARCB1 expression has been reported in gastrointestinal carcinomas. Our purpose was to evaluate the incidence and prognostic value of SMARCB1 loss in colon carcinoma (CC). Patients with stage III CC (n = 1695), and a second cohort of 23 patients with poorly differentiated CC were analyzed. Immunohistochemistry for SMARCB1 was performed on tissue microarrays, and cases with loss of expression were controlled on whole sections. Loss of SMARCB1 was compared with the clinico-pathological and molecular characteristics, and the prognostic value was evaluated. Loss of SMARCB1 was identified in 12 of 1695 (0.7%) patients with stage III CC. Whole section controls showed a complete loss in only one of these cases, corresponding to a medullary carcinoma. SMARCB1 loss was not associated with histological grade, tumor size nor survival. In the cohort of poorly differentiated CC, we detected 2/23 (8.7%) cases with loss of SMARCB1; one was rhabdoid while the other had medullary and mucinous histology. These 2 cases were deficient for MisMatched Repair (dMMR) and mutated for BRAF. SMARCB1 loss is rare in stage III CC, but appears more frequent in poorly differentiated CC.
Document type :
Journal articles
Complete list of metadatas

Cited literature [39 references]  Display  Hide  Download
Contributor : Laurent Jonchère <>
Submitted on : Friday, June 12, 2020 - 3:20:54 PM
Last modification on : Tuesday, January 19, 2021 - 4:42:33 PM


Melloul-2020-Loss of SMARCB1 e...
Files produced by the author(s)



S. Melloul, J-F Mosnier, J. Masliah-Planchon, C. Lepage, K. Le Malicot, et al.. Loss of SMARCB1 expression in colon carcinoma. Cancer Biomarkers, IOS Press, 2020, 27 (3), pp.399-406. ⟨10.3233/CBM-190287⟩. ⟨hal-02798007⟩



Record views


Files downloads