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Personality dimensions are associated with quality of life in fluctuating Parkinson's disease patients (PSYCHO-STIM)

Mathilde Boussac 1, * Christophe Arbus 2 Julia Dupouy 3 Estelle Harroch 3 Vanessa Rousseau 3 Fabienne Ory-Magne 3, 1, 2 Olivier Rascol 3 Caroline Moreau 4 David Maltête 5 Tiphaine Rouaud 6 Mylène Meyer 7 Jean Francois Houvenaghel 8, 9 Claire Marsé 10 Christine Tranchant 11, 12 Elodie Hainque 13, 14 Bechir Jarraya 15 Solène Ansquer 16 Marie Bonnet 17 Lhaouas Belamri 18 Fazia Mélissa Tir 19 Ana-Raquel Marques 20, 21 Teodor Danaila 22 Alexandre Eusebio 23 David Devos 4 Christine Brefel-Courbon 24, 3
* Corresponding author
1 ToNIC - Toulouse Neuro Imaging Center
2 CHU Toulouse [Toulouse]
3 CIC 1436 - Centre d'investigation clinique de Toulouse
4 TCDV - Troubles cognitifs dégénératifs et vasculaires - U 1171
5 DC2N - Différenciation et communication neuronale et neuroendocrine
6 Clinique neurologique
7 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
8 CHU Pontchaillou [Rennes]
9 Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes]
10 CHU Nice - Centre Hospitalier Universitaire de Nice
11 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
12 CHU Strasbourg
13 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
14 CHU Pitié-Salpêtrière [AP-HP]
15 UNICOG-U992 - Neuroimagerie cognitive - Psychologie cognitive expérimentale
16 CIC - Poitiers
17 CHU Bordeaux [Bordeaux]
18 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
19 LNFP - Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559
20 NPsy-Sydo - Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux
21 UCA - Université Clermont Auvergne
22 HCL - Hospices Civils de Lyon
23 INT - Institut de Neurosciences de la Timone
24 CHU Casselardit - Junod
Abstract : Background:Parkinson’s disease (PD) negatively affects patients’ Quality of Life (QoL) which depends on both objective criteria such as physical health and subjective ones such as worries and norms according to personal believes. Therefore, QoL could be also associated to personality dimensions in chronic neurological diseases such as PD. Objective:Our objective was thus to study the potential association between personality dimensions and QoL in PD patients with motor fluctuations before Deep Brain Stimulation of the Sub-Thalamic Nucleus (DBS-STN). Methods:Data were obtained from the French multicentric cohort study Predi-Stim. All PD patients awaiting DBS-STN and responding to the inclusion criteria at the time of the study were included. All participants answered the “Temperament and Character Inventory” (TCI) and the PDQ-39 before surgery. Analyses were made using adjusted univariate generalized linear regression models to evaluate a potential association between TCI dimensions and PDQ-39 scores. Results:Three hundred thirty-three consecutive patients were included. The temperament Harm Avoidance was negatively associated with QoL (p = 1e-4, R2= 0.33), whereas the character Self-Directedness was positively associated with mental component of QoL (p = 2e-4, R2= 0.33) in PD patients with motor fluctuations awaiting DBS-STN. Conclusions:PD patients with motor fluctuations, with lower Harm Avoidance and higher Self-Directedness scores have the best QoL mainly at an emotional and social level. Therapeutic education of these PD patients focusing on their personal resources may thus be important to improve their well-being.
Keywords : Character Parkinson’s disease personality quality of life temperament
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Journal articles
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-02859933
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Tuesday, June 16, 2020 - 10:29:37 AM
Last modification on : Tuesday, January 18, 2022 - 9:58:20 AM

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UNIV-RENNES1 | NPSY-SYDO | UNIV-RENNES | UNIROUEN | UNIV-LILLE | UNIV-AMU | DC2N | SORBONNE-UNIVERSITE | SU-MEDECINE | CNRS | PRES_CLERMONT | SITE-ALSACE | COMUE-NORMANDIE | ICM | IGBMC | UNIV-TLSE3 | UNIV-POITIERS | CIC | HCL | UR1-UFR-SVE | BIOSIT | INT | CEA | CNGC | UR1-BIO-SA | U-PICARDIE | LNFP | NEUROMARSEILLE

Citation

Mathilde Boussac, Christophe Arbus, Julia Dupouy, Estelle Harroch, Vanessa Rousseau, et al.. Personality dimensions are associated with quality of life in fluctuating Parkinson's disease patients (PSYCHO-STIM). Journal of Parkinson's disease, Amsterdam : b : IOS Press, 2020, 10 (3), pp.1057-1066. ⟨10.3233/JPD-191903⟩. ⟨hal-02859933⟩

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