, Behavior and Behavior Mechanisms, Bisphenol), p.AND ((((((((((((

, Sexual Behavior, Animal"[Mesh] OR "Sexual Behavior

, Behavior, Animal"[Mesh])) OR "Mental Disorders, Mesh])) OR (Behavior OR Neurobehavior OR Neurodevelopment OR Neurology OR Parkinson OR Alzheimer OR Autism OR Hyperactivity OR ASD OR ADHD OR mental retardation OR IQ loss OR internalizing OR externalizing

, Liver Neoplasms"[Mesh] OR "Hereditary Breast and Ovarian Cancer Syndrome, Cancer

, OR (Cancer OR hormone-dependent cancer OR neoplasm OR malignant tumor OR tumor OR tumour) OR, Neoplasms, Germ Cell and Embryonal

N. Mukmeneva, E. Gotlib, M. Verizhnikov, G. Nagumanova, L. Grinberg et al., The influence of bisphenol antioxidants on thermo-oxidative degradation of plasticised poly(vinyl chloride), Polym. Degrad. Stabil, vol.73, pp.383-386, 2001.

, Scientific Opinion on the Risks to Public Health Related to the Presence of Bisphenol A (BPA) in Foodstuffs: Executive Summary, EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF). 2015. Available online, p.20, 2020.

N. R. Gassman, Induction of oxidative stress by bisphenol A and its pleiotropic effects, Environ. Mol. Mutagen, vol.58, pp.60-71, 2017.

S. Babu, S. Uppu, M. O. Claville, and R. M. Uppu, Prooxidant actions of bisphenol A (BPA) phenoxyl radicals: Implications to BPA-related oxidative stress and toxicity, Toxicol. Mech. Methods, vol.23, pp.273-280, 2013.

A. Atkinson and D. Roy, In vitro conversion of environmental estrogenic chemical bisphenol A to DNA binding metabolite(s), Biochem. Biophys. Res. Commun, vol.210, pp.424-433, 1995.

A. Atkinson and D. Roy, In-Vivo DNA Adduct Formation by Bisphenol-A. Environ. Mol. Mutagen, vol.26, pp.60-66, 1995.

B. Halliwell and J. M. Gutteridge, Free Radicals in Biology and Medicine, 2015.

T. Hofer, Oxidation of 2'-deoxyguanosine by H 2 O 2 -ascorbate: Evidence against free OH ? and thermodynamic support for two-electron reduction of H 2 O 2, J. Chem. Soc. Perk. Trans, vol.2, pp.210-213, 2001.

A. Valavanidis, T. Vlachogianni, and C. Fiotakis, 8-hydroxy-2 -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis, J. Environ. Sci. Health C. Environ. Carcinog. Ecotoxicol. Rev, vol.27, pp.120-139, 2009.

T. Hofer, C. Badouard, E. Bajak, J. L. Ravanat, A. Mattsson et al., Hydrogen peroxide causes greater oxidation in cellular RNA than in DNA, Biol. Chem, vol.386, pp.333-337, 2005.

J. Alary, F. Bravais, J. P. Cravedi, L. Debrauwer, D. Rao et al., Mercapturic acid conjugates as urinary end metabolites of the lipid peroxidation product 4-hydroxy-2-nonenal in the rat, Chem. Res. Toxicol, vol.8, pp.34-39, 1995.

M. L. Hu, Measurement of Protein Thiol-Groups and Glutathione in Plasma, Method. Enzymol, vol.233, pp.380-385, 1994.

V. Mustieles, S. C. Cruz, S. Couderq, A. Rodriguez-carrillo, J. Fini et al., Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring, Environ. Int, 2020.

M. Dallio, M. Masarone, S. Errico, A. G. Gravina, C. Nicolucci et al., Role of bisphenol A as environmental factor in the promotion of non-alcoholic fatty liver disease: In vitro and clinical study, Aliment. Pharm. Ther, vol.47, pp.826-837, 2018.

D. E. Kleiner, E. M. Brunt, M. Van-natta, C. Behling, M. J. Contos et al., Nonalcoholic Steatohepatitis Clinical Research, N., Design and validation of a histological scoring system for nonalcoholic fatty liver disease, Hepatology, vol.41, pp.1313-1321, 2005.

Y. Li, H. Zhang, H. Kuang, R. Fan, C. Cha et al., Relationship between bisphenol A exposure and attention-deficit/hyperactivity disorder: A case-control study for primary school children in Guangzhou, China. Environ. Pollut, vol.235, pp.141-149, 2018.

F. M. Metwally, H. Rashad, H. M. Zeidan, A. Kilany, and E. R. Raouf, Study of the Effect of Bisphenol A on Oxidative Stress in Children with, Autism Spectrum Disorders. Indian J. Clin. Biochem, vol.33, pp.196-201, 2018.

M. Kondolot, E. N. Ozmert, A. Asci, P. Erkekoglu, D. B. Oztop et al., Plasma phthalate and bisphenol a levels and oxidant-antioxidant status in autistic children, Environ. Toxicol. Phar, vol.43, pp.149-158, 2016.

E. S. Erden, S. Motor, I. Ustun, M. Demirkose, R. Yuksel et al., Investigation of Bisphenol A as an endocrine disruptor, total thiol, malondialdehyde, and C-reactive protein levels in chronic obstructive pulmonary disease, Eur. Rev. Med. Pharmacol. Sci, vol.18, pp.3477-3483, 2014.

G. A. Omran, H. D. Gaber, N. A. Mostafa, R. M. Abdel-gaber, and E. A. Salah, Potential hazards of bisphenol A exposure to semen quality and sperm DNA integrity among infertile men, Reprod. Toxicol, vol.81, pp.188-195, 2018.

M. Yang, H. S. Lee, M. W. Hwang, and M. Jin, Effects of Korean red ginseng (Panax Ginseng Meyer) on bisphenol A exposure and gynecologic complaints: Single blind, randomized clinical trial of efficacy and safety, BMC Complement. Altern. Med, vol.14, 2014.

K. K. Ferguson, D. E. Cantonwine, T. F. Mcelrath, B. Mukherjee, and J. D. Meeker, Repeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy, Reprod. Toxicol, vol.66, pp.93-98, 2016.

D. J. Watkins, K. K. Ferguson, L. V. Toro, A. N. Alshawabkeh, J. F. Cordero et al., Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico, Int. J. Hyg. Envir. Heal, vol.218, pp.212-219, 2015.

A. Veiga-lopez, S. Pennathur, K. Kannan, H. B. Patisaul, D. C. Dolinoy et al., Gestational Bisphenol A on Oxidative Stress and Free Fatty Acids: Human Association and Interspecies Animal Testing Studies, vol.156, pp.911-922, 2015.

Y. F. Huang, P. W. Wang, L. W. Huang, C. H. Lai, W. N. Yang et al., Prenatal Nonylphenol and Bisphenol A Exposures and Inflammation Are Determinants of Oxidative/Nitrative Stress: A Taiwanese Cohort Study, Environ. Sci. Technol, vol.51, pp.6422-6429, 2017.

Y. F. Huang, P. W. Wang, L. W. Huang, M. H. Lin, W. Yang et al., Interactive effects of nonylphenol and bisphenol A exposure with oxidative stress on fetal reproductive indices, Environ. Res, vol.167, pp.567-574, 2018.

C. H. Chang, Y. F. Huang, P. W. Wang, C. H. Lai, L. W. Huang et al., Associations between prenatal exposure to bisphenol a and neonatal outcomes in a Taiwanese cohort study: Mediated through oxidative stress? Chemosphere, vol.226, pp.290-297, 2019.

Y. Zhou, Y. Yao, Y. Shao, W. Qu, Y. Chen et al., Urinary bisphenol analogues concentrations and biomarkers of oxidative DNA and RNA damage in Chinese school children in East China: A repeated measures study, Environ. Pollut, vol.254, 2019.

B. A. Rocha, A. G. Asimakopoulos, M. Honda, N. L. Da-costa, R. M. Barbosa et al., Advanced data mining approaches in the assessment of urinary concentrations of bisphenols, chlorophenols, parabens and benzophenones in Brazilian children and their association to DNA damage, Environ. Int, vol.116, pp.269-277, 2018.

R. Bono, V. Bellisario, R. Tassinari, G. Squillacioti, T. Manetta et al., Tobacco Smoke, and Age as Predictors of Oxidative Stress in Children and Adolescents, Int. J. Environ. Res. Public Health, vol.16, 2019.

Y. S. Lv, C. Y. Rui, Y. Y. Dai, Q. H. Pang, Y. R. Li et al., Exposure of children to BPA through dust and the association of urinary BPA and triclosan with oxidative stress in Guangzhou, China. Environ. Sci.-Proc. Imp, vol.18, pp.1492-1499, 2016.

Y. X. Wang, C. Liu, Y. Shen, Q. Wang, A. Pan et al., Urinary levels of bisphenol A, F and S and markers of oxidative stress among healthy adult men: Variability and association analysis, Environ. Int, vol.123, pp.301-309, 2019.

Y. C. Hong, E. Y. Park, M. S. Park, J. A. Ko, S. Y. Oh et al., Community level exposure to chemicals and oxidative stress in adult population, Toxicol. Lett, vol.184, pp.139-144, 2009.

Y. J. Yang, Y. C. Hong, S. Y. Oh, M. S. Park, H. Kim et al., Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women, Environ. Res, vol.109, pp.797-801, 2009.

A. G. Asimakopoulos, J. C. Xue, B. P. De-carvalho, A. Iyer, K. O. Abualnaja et al., Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia, Environ. Res, vol.150, pp.573-581, 2016.

M. Liu, S. Jia, T. Dong, Y. Han, J. Xue et al., The occurrence of bisphenol plasticizers in paired dust and urine samples and its association with oxidative stress, Chemosphere, vol.216, pp.472-478, 2019.

Y. Choi, S. J. Lee, J. Jeon, K. J. Jung, and S. H. Jee, Inverse associations of bisphenol A and phthalate metabolites with serum bilirubin levels in Korean population, Environ. Sci. Pollut. Res. Int, vol.26, pp.26685-26695, 2019.

B. Yi, H. Kasai, H. S. Lee, Y. Kang, J. Y. Park et al., Inhibition by wheat sprout (Triticum aestivum) juice of bisphenol A-induced oxidative stress in young women, Mutat. Res.-Gen. Tox. En, vol.724, pp.64-68, 2011.

J. H. Kim, M. R. Lee, and Y. C. Hong, Modification of the association of bisphenol A with abnormal liver function by polymorphisms of oxidative stress-related genes, Environ. Res, vol.147, pp.324-330, 2016.

J. H. Kim and Y. C. Hong, Increase of urinary malondialdehyde level by bisphenol A exposure: A longitudinal panel study, vol.16, 2017.

T. Zhang, J. C. Xue, C. Z. Gao, R. L. Qiu, Y. X. Li et al., Urinary Concentrations of Bisphenols and Their Association with Biomarkers of Oxidative Stress in People Living Near E-Waste Recycling Facilities in China, Environ. Sci. Technol, vol.50, pp.4045-4053, 2016.

D. R. Janero, Malondialdehyde and Thiobarbituric Acid-Reactivity as Diagnostic Indexes of Lipid-Peroxidation and Peroxidative Tissue-Injury. Free Radic, Biol. Med, vol.9, pp.515-540, 1990.

S. Zelzer, R. Oberreither, C. Bernecker, I. Stelzer, M. Truschnig-wilders et al., Measurement of total and free malondialdehyde by gas-chromatography mass spectrometry-comparison with high-performance liquid chromatography methology, Free Radic. Res, vol.47, pp.651-656, 2013.

D. Grotto, L. S. Maria, J. Valentini, C. Paniz, G. Schmitt et al., Importance of the Lipid Peroxidation Biomarkers and Methodological Aspects for Malondialdehyde Quantification, Quim, vol.32, pp.169-174, 2009.

D. Tsikas, S. Rothmann, J. Y. Schneider, M. T. Suchy, A. Trettin et al., Development, validation and biomedical applications of stable-isotope dilution GC-MS and GC-MS/MS techniques for circulating malondialdehyde (MDA) after pentafluorobenzyl bromide derivatization: MDA as a biomarker of oxidative stress and its relation to 15(S)-8-iso-prostaglandin F2alpha

, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci, vol.1019, pp.95-111, 2016.

V. Mustieles and J. P. Arrebola, How polluted is your fat? What the study of adipose tissue can contribute to environmental epidemiology, J. Epidemiol. Community Health, vol.74, pp.401-407, 2020.

Q. Sun, K. A. Bertrand, A. A. Franke, B. Rosner, G. C. Curhan et al., Reproducibility of urinary biomarkers in multiple 24-h urine samples, Am. J. Clin. Nutr, vol.105, pp.159-168, 2017.

C. Vernet, C. Philippat, L. Agier, A. M. Calafat, X. Ye et al., An Empirical Validation of the Within-subject Biospecimens Pooling Approach to Minimize Exposure Misclassification in Biomarker-based Studies, Epidemiology, vol.30, pp.756-767, 2019.

L. E. Johns, G. S. Cooper, A. Galizia, and J. D. Meeker, Exposure assessment issues in epidemiology studies of phthalates, Environ. Int, vol.85, pp.27-39, 2015.

J. B. Knaak and L. J. Sullivan, Metabolism of bisphenol A in the rat, Toxicol. Appl. Pharmacol, vol.8, pp.175-184, 1966.

P. Kovacic, How safe is bisphenol A? Fundamentals of toxicity: Metabolism, electron transfer and oxidative stress, Med. Hypotheses, vol.75, pp.1-4, 2010.

S. Sakuma, M. Nakanishi, K. Morinaga, M. Fujitake, S. Wada et al., Bisphenol A 3,4-quinone induces the conversion of xanthine dehydrogenase into oxidase in vitro, Food Chem. Toxicol, vol.48, pp.2217-2222, 2010.

M. Yoshida, H. Ono, Y. Mori, Y. Chuda, and K. Onishi, Oxidation of bisphenol A and related compounds, Biosci. Biotechnol. Biochem, vol.65, pp.1444-1446, 2001.

S. Kitamura, T. Suzuki, S. Sanoh, R. Kohta, N. Jinno et al., Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds, Toxicol. Sci, vol.84, pp.249-259, 2005.

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