, Haiman had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis

. Wan, . Sheng, . Xia, . Gundell, . Pooler et al.,

. Darst, . Conti, . Haiman, . Wan, . Sheng et al., Drafting of the manuscript: Darst, Conti, Haiman. Critical revision of the manuscript for important intellectual content: Sheng, Statistical analysis: Darst, Conti, Wan, Sheng, Xia. Obtaining funding: Conti

, Administrative, technical, or material support: Wan, Sheng, Xia, Gundell, Pooler. Supervision: Haiman. Other: None

, Haiman certifies that all conflicts of interest, including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg, employment/affiliation, grants or funding, consultancies, honoraria, stock ownership or options, expert testimony, royalties, or patents filed, received

, Funding/Support and role of the sponsor: This work was supported by the National Cancer Institute at the National Institutes of Health (grants U19 CA148537, U19 CA214253, R01 CA165862, and K99 CA246063)

F. Burcu, Darst was supported in part by an award from the Achievement Rewards for College Scientists Foundation Los Angeles Founder Chapter

J. L. Stanford and E. A. Ostrander, Familial prostate cancer, Epidemiol Rev, vol.23, pp.19-23, 2001.
URL : https://hal.archives-ouvertes.fr/hal-02860251

C. M. Ewing, A. M. Ray, and E. M. Lange, Germline mutations in HOXB13 and prostate-cancer risk, N Engl J Med, vol.366, pp.141-150, 2012.

J. Xu, E. M. Lange, and L. Lu, HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG), Hum Genet, vol.132, pp.5-14, 2013.

V. N. Giri, S. E. Hegarty, and C. Hyatt, Germline genetic testing for inherited prostate cancer in practice: implications for genetic testing, precision therapy, and cascade testing, Prostate, vol.79, pp.333-342, 2019.

D. V. Conti, K. Wang, and X. Sheng, Two novel susceptibility loci for prostate cancer in men of African ancestry, J Natl Cancer Inst, vol.109, p.84, 2017.

M. L. Freedman, C. A. Haiman, and N. Patterson, Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men, Proc Natl Acad Sci, vol.103, pp.14068-73, 2006.

C. A. Haiman, N. Patterson, and M. L. Freedman, Multiple regions within 8q24 independently affect risk for prostate cancer, Nat Genet, vol.39, pp.638-682, 2007.

M. Matejcic, E. J. Saunders, and T. Dadaev, Germline variation at 8q24 and prostate cancer risk in men of European ancestry, Nat Commun, vol.9, p.4616, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01924689

J. R. Prensner, W. Chen, and S. Han, The long non-coding RNA PCAT-1 promotes prostate cancer cell proliferation through cMyc, Neoplasia, vol.16, pp.900-908, 2014.

T. Kim, R. Cui, and Y. J. Jeon, Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA

, Proc Natl Acad Sci U S A, vol.111, pp.4173-4181, 2014.

V. N. Giri, K. E. Knudsen, and W. K. Kelly, Role of genetic testing for inherited prostate cancer risk: Philadelphia Prostate Cancer Consensus Conference, J Clin Oncol, vol.36, pp.414-438, 2017.

. E-u-r-o-p-e-a-n-u-r-o-l-o-g-y,