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Journal articles
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response
Estefanie Dufey
1
José Manuel Bravo-San Pedro
2
Cristian Eggers
1
Matías González-Quiroz
1, 3, 4
Hery Urra
1
Alfredo I Sagredo
1
Denisse Sepulveda
1
Philippe Pihán
1
Amado Carreras-Sureda
1
Younis Hazari
1
Eduardo A Sagredo
5
Daniela Gutierrez
6
Cristian Valls
6
Alexandra Papaioannou
3, 4
Diego Acosta-Alvear
7, 8
Gisela Campos
9, 10
Pedro M Domingos
11
Remy Pedeux
3, 4
Eric Chevet
3, 4
Alejandra Alvarez
6
Patricio Godoy
10
Peter Walter
7
Álvaro Glavic
1
Guido Kroemer
2, 12, 13
Claudio Hetz
1
Estefanie Dufey 1
Author
José Manuel Bravo-San Pedro 2
Author
Cristian Eggers 1
Author
Matías González-Quiroz 1, 3, 4
Author
Amado Carreras-Sureda 1
Author
Younis Hazari 1
Author
Eduardo A Sagredo 5
Author
Daniela Gutierrez 6
Author
Cristian Valls 6
Author
Alexandra Papaioannou 3, 4
Author
Diego Acosta-Alvear 7, 8
Author
Gisela Campos 9, 10
Author
Pedro M Domingos 11
Author
Remy Pedeux 3, 4
Author
Eric Chevet 3, 4
Author
Alejandra Alvarez 6
Author
Patricio Godoy 10
Author
Peter Walter 7
Author
Álvaro Glavic 1
Author
Guido Kroemer 2, 12, 13
Author
Claudio Hetz 1
Author
1
UCHILE - Universidad de Chile = University of Chile [Santiago] (Av. Libertador Bernardo O'Higgins 1058, Santiago de Chile - Chile)
2
CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers (15 rue de l'Ecole de Médecine - Bâtiment B -
75270 Paris Cedex 06 - France)
- EPHE - École pratique des hautes études (4-14 Rue Ferrus, 75014 Paris - France)
- PSL - Université Paris sciences et lettres (60 rue Mazarine 75006 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1138 (101, rue de Tolbiac, 75013 Paris - France)
- SU - Sorbonne Université (21 rue de l’École de médecine - 75006 Paris - France)
- UP - Université de Paris : UMR_S_1138 (85 boulevard Saint-Germain 75006 Paris - France)
3
COSS - Chemistry, Oncogenesis, Stress and Signaling (Université de Rennes1 - CLCC Eugène Marquis, Rue de la Bataille Flandres Dunkerque, Bat D, 35042 Rennes - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
- CRLCC - CRLCC Eugène Marquis (Avenue Bataille Flandres-Dunkerque 35042 RENNES CEDEX - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1242 (101, rue de Tolbiac, 75013 Paris - France)
4
CRLCC - Centre Eugène Marquis (Avenue Bataille Flandres-Dunkerque 35042 RENNES CEDEX - France)
5
Stockholm University (Stockholm University, SE-106 91 Stockholm, Sweden - Sweden)
6
UC - Pontificia Universidad Católica de Chile (Casilla 306, Santiago 22 - Chile)
7
University of the Pacific [San Francisco] (San Francisco Campus
155 Fifth Street, San Francisco, California 94103 - United States)
- University of the Pacific (United States)
8
UCSB - University of California [Santa Barbara] (Santa Barbara, CA 93106 - United States)
- University of California (United States)
9
TU - Technische Universität Dortmund [Dortmund] (44221 Dortmund - Germany)
10
IFADO - Leibniz Research Centre for Working Environment and Human Factors [Dortmund] (Ardeystraße 67
D-44139 Dortmund - Germany)
- TU - Technische Universität Dortmund [Dortmund] (44221 Dortmund - Germany)
11
NOVA - Universidade Nova de Lisboa = NOVA University of Lisboa (Campus de Campolide
1099-085 Lisboa - Portugal)
12
Pôle de biologie (75015 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- HEGP - Hôpital Européen Georges Pompidou [APHP] (20, rue Leblanc, 75015 Paris - France)
13
Karolinska Institutet [Stockholm] (Solnavägen 1, 171 77 Solna
Stockholm - Sweden)
Abstract : The molecular connections between homeostatic systems that maintain both genome integrity and proteostasis are poorly understood. Here we identify the selective activation of the unfolded protein response transducer IRE1α under genotoxic stress to modulate repair programs and sustain cell survival. DNA damage engages IRE1α signaling in the absence of an endoplasmic reticulum (ER) stress signature, leading to the exclusive activation of regulated IRE1α-dependent decay (RIDD) without activating its canonical output mediated by the transcription factor XBP1. IRE1α endoribonuclease activity controls the stability of mRNAs involved in the DNA damage response, impacting DNA repair, cell cycle arrest and apoptosis. The activation of the c-Abl kinase by DNA damage triggers the oligomerization of IRE1α to catalyze RIDD. The protective role of IRE1α under genotoxic stress is conserved in fly and mouse. Altogether, our results uncover an important intersection between the molecular pathways that sustain genome stability and proteostasis.
Document type :
Journal articles
Domain :
Complete list of metadatas
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02862260
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, June 9, 2020 - 1:43:44 PM
Last modification on : Friday, September 18, 2020 - 2:35:08 PM
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, June 9, 2020 - 1:43:44 PM
Last modification on : Friday, September 18, 2020 - 2:35:08 PM
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Licence
Distributed under a Creative Commons Attribution 4.0 International License
Identifiers
- HAL Id : hal-02862260, version 1
- DOI : 10.1038/s41467-020-15694-y
- PUBMED : 32409639
Collections
OSS | UNIV-RENNES1 | MARQUIS | FNCLCC | BIOSIT | UR1-UFR-SVE | UNIV-RENNES | SORBONNE-UNIVERSITE | CORDELIERS | EPHE | UP-SANTE | SU-SCIENCES | UNIV-PARIS | PSL
Citation
Estefanie Dufey, José Manuel Bravo-San Pedro, Cristian Eggers, Matías González-Quiroz, Hery Urra, et al.. Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response. Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2401. ⟨10.1038/s41467-020-15694-y⟩. ⟨hal-02862260⟩
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