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Roles of CDK/Cyclin complexes in transcription and pre-mRNA splicing Cyclins L and CDK11 at the cross-roads of cell cycle and regulation of gene expression

Abstract : Cyclin Dependent Kinases (CDKs) represent a large family of serine/threonine protein kinases that become active upon binding to a Cyclin regulatory partner. CDK/cyclin complexes recently identified, as well as "canonical" CDK/Cyclin complexes regulating cell cycle, are implicated in the regulation of gene expression via the phosphorylation of key components of the transcription and pre-mRNA processing machineries. In this review, we summarize the role of CDK/cyclin-dependent phosphorylation in the regulation of transcription and RNA splicing and highlight recent findings that indicate the involvement of CDK11/cyclin L complexes at the cross-roads of cell cycle, transcription and RNA splicing. Finally, we discuss the potential of CDK11 and Cyclins L as therapeutic targets in cancer.
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Submitted on : Wednesday, July 1, 2020 - 11:15:52 AM
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Pascal Loyer, Janeen H Trembley. Roles of CDK/Cyclin complexes in transcription and pre-mRNA splicing Cyclins L and CDK11 at the cross-roads of cell cycle and regulation of gene expression. Seminars in Cell and Developmental Biology, Elsevier, 2020, ⟨10.1016/j.semcdb.2020.04.016⟩. ⟨hal-02864472⟩

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