Diesel Engine Exhaust Exposure, Smoking, and Lung Cancer Subtype Risks: A Pooled Exposure-response Analysis of 14 Case–control Studies

Calvin Ge , Susan Peters (1) , Ann Olsson (2) , Lützen Portengen (3) , Joachim Schüz (2) , Josue Almansa (3) , Wolfgang Ahrens (4) , Vladimir Bencko (5) , Simone Benhamou (6) , Paolo Boffetta (7) , Bas Bueno-De-Mesquita (8) , Neil E. Caporaso (9) , Dario Consonni (10) , Paul Demers (11) , Eleonora Fabianova (12) , Guillermo Fernández-Tardón , John Field , Francesco Forastiere (13) , Lenka Foretova (14) , Pascal Guénel (15, 16) , Per Gustavsson (17) , Vladimir Janout (18) , Karl-Heinz Jöckel (19) , Stefan Karrasch , Maria Teresa Landi (9) , Jolanta Lissowska (20) , Danièle Luce (21) , Dana Mates (22) , John Mclaughlin (23) , Franco Merletti (24) , Dario Mirabelli (24) , Tamás Pándics , Marie-Elise Parent (25) , Nils Plato (17) , Hermann Pohlabeln (26) , Lorenzo Richiardi (24) , Jack Siemiatycki (27) , Beata Świątkowska , Adonina Tardón (28) , Heinz-Erich Wichmann (29) , David Zaridze (30) , Kurt Straif (2) , Hans Kromhout (1) , Roel Vermeulen (1)

1 Division of Environmental Epidemiology
2 CIRC - IARC - Centre International de Recherche contre le Cancer - International Agency for Research on Cancer
3 Institute for Risk Assessment Sciences
4 Bremen Institute for Prevention Research and Social Medicine (BIPS), Division of Epidemiological Methods and Etiologic Research
5 Institute of Hygiene and Epidemiology
6 Variabilité Génétique et Maladies Humaines
7 MSSM - Icahn School of Medicine at Mount Sinai [New York]
8 DCD - Department for Determinants of Chronic Diseases
9 NCI-NIH - National Cancer Institute [Bethesda]
10 Unit of Epidemiology
11 University of Toronto
12 RAPH - Regional Authority of Public Health [Slovaquia]
13 ASL - Azienda Sanitaria Locale [ROMA]
14 MMCI - Masaryk Memorial Cancer Institute
15 Epidémiologie environnementale des cancers
16 CESP - Centre de recherche en épidémiologie et santé des populations
17 IMM - The Institute of Environmental Medicine [Stockholm]
18 Faculty of Medicine
19 Institute for Medical Informatics, Biometry, and Epidemiology
20 Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
21 IRSET-ESTER - Épidémiologie en Santé au Travail et Ergonomie
22 Institute of Public Health
23 Cancer Care Ontario
24 Cancer Epidemiology Unit
25 INRS-IAF - Institut Armand Frappier
26 Bremen Institute for Prevention Research and Social Medicine
27 CHUM - Centre Hospitalier de l'Université de Montréal
28 Molecular Epidemiology of Cancer Unit
29 King‘s College London
30 Institute of Carcinogenesis

We expanded upon a previous pooled case-control analysis on diesel engine exhaust and lung cancer by including 3 additional studies and quantitative exposure assessment to evaluate lung cancer and subtype risks associated with occupational exposure to diesel exhaust, characterized by elemental carbon (EC) concentrations.

Keywords: Occupational exposure; diesel exhaust; epidemiology; lung neoplasms

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Santé publique et épidémiologie

Calvin Ge, Susan Peters, Ann Olsson, Lützen Portengen, Joachim Schüz, et al.. Diesel Engine Exhaust Exposure, Smoking, and Lung Cancer Subtype Risks: A Pooled Exposure-response Analysis of 14 Case–control Studies. American Journal of Respiratory and Critical Care Medicine, 2020, 202 (3), pp.402-411. ⟨10.1164/rccm.201911-2101OC⟩. ⟨hal-02866675⟩