Remote Deprotometalation-Iodolysis of N,N-Diisopropyl-2-trimethylsilylferrocenecarboxamide: A New Route Toward 1,1′-Disubstituted Ferrocenes - Archive ouverte HAL Access content directly
Journal Articles Synthesis: Journal of Synthetic Organic Chemistry Year : 2020

Remote Deprotometalation-Iodolysis of N,N-Diisopropyl-2-trimethylsilylferrocenecarboxamide: A New Route Toward 1,1′-Disubstituted Ferrocenes

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Abstract

The 1,1′-disubstitution is currently the most frequent substitution pattern encountered in the ferrocene series. Here an original access based on the remote deprotometalation of N,N-diisopropyl-2-trimethylsilylferrocenecarboxamide is reported. The key intermediate, 1′-iodo-N,N-diisopropylferrocenecarboxamide, was prepared in multiple grams and was further functionalized toward fifteen 1′-substituted iodoferrocenes.
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hal-02948487 , version 1 (03-12-2020)

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Lingaswamy Kadari, Thierry Roisnel, William Erb, Palakodety Radha Krishna, Florence Mongin. Remote Deprotometalation-Iodolysis of N,N-Diisopropyl-2-trimethylsilylferrocenecarboxamide: A New Route Toward 1,1′-Disubstituted Ferrocenes. Synthesis: Journal of Synthetic Organic Chemistry, 2020, 52 (21), pp.3153-3161. ⟨10.1055/s-0040-1707175⟩. ⟨hal-02948487⟩
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