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Mitochondrial Transport, Partitioning and Quality Control at the Heart of Cell Proliferation and Fate Acquisition

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Abstract

Mitochondria are essential to cell homeostasis, and alterations in mitochondrial distribution, segregation or turnover have been linked to complex pathologies such as neurodegenerative diseases or cancer. Understanding how these functions are coordinated in specific cell types is a major challenge to discover how mitochondria globally shape cell functionality. In this review, we will first describe how mitochondrial transport and dynamics are regulated throughout the cell cycle in yeast and in mammals. Second, we will explore the functional consequences of mitochondrial transport and partitioning on cell proliferation, fate acquisition, stemness, and on the way cells adapt their metabolism. Last, we will focus on how mitochondrial clearance programs represent a further layer of complexity for cell differentiation, or in the maintenance of stemness. Defining how mitochondrial transport, dynamics and clearance are mutually orchestrated in specific cell types may help our understanding of how cells can transition from a physiological to a pathological state.
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hal-03383673 , version 1 (18-10-2021)

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Attribution - CC BY 4.0

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Rakesh Kumar Sharma, Abderrahman Chafik, Giulia Bertolin. Mitochondrial Transport, Partitioning and Quality Control at the Heart of Cell Proliferation and Fate Acquisition. 2021. ⟨hal-03383673⟩
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