ABO blood group does not influence Child‐Pugh A cirrhosis outcome: An observational study from CIRRAL and ANRS CO12 CIRVIR cohorts

Isabelle Ollivier-Hourmand (1) , Yohann Repesse (1) , Pierre Nahon (2) , Cendrine Chaffaut (3) , Thông Dao (1) , Thi Thu Nga Nguyen (1) , Patrick Marcellin , Dominique Roulot (4) , Victor de Ledinghen , Stanislas Pol (5) , Dominique Guyader (6, 7) , Isabelle Archambeaud , Fabien Zoulim (8) , Frédéric Oberti (9) , Albert Tran (10) , Jean-Pierre Bronowicki , Louis d'Alteroche , Denis Ouzan (11) , Jean-Marie Peron (12) , Jean-Pierre Zarski (13) , Marc Bourliere , Dominique Larrey , Alexandre Louvet , Paul Cales , Armand Abergel , Philippe Mathurin , Ariane Mallat , Jean-Frederic Blanc , Eric Nguyen-Khac (14) , Ghassan Riachi (15, 16, 17, 18) , Laurent Alric (19) , Lawrence Serfaty , Teresa Antonini , Christophe Moreno , Pierre Attali , Dominique Thabut , Christophe Pilette , Jean-Didier Grange , Christine Silvain , Nicolas Carbonell , Brigitte Bernard-Chabert , Odile Goria (15, 16, 17, 18) , Claire Wartelle , Romain Moirand (7, 6) , Christos Christidis , Gabriel Perlemuter , Violaine Ozenne , Jean Henrion , Sophie Hillaire , Vincent Di Martino , Xavier Amiot , Angela Sutton (2, 4) , Nathalie Barget (2, 4) , Sylvie Chevret (20) , Nathalie Ganne‐carrie (2, 4)

1 CHU Caen
2 CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers
3 CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
4 Hôpital Avicenne [AP-HP]
5 IC UM3 (UMR 8104 / U1016) - Institut Cochin
6 NuMeCan - Nutrition, Métabolismes et Cancer
7 CHU Pontchaillou [Rennes]
8 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
9 CHU Angers - Centre Hospitalier Universitaire d'Angers
10 C3M - Centre méditerranéen de médecine moléculaire
11 Institut Arnault Tzanck
12 Pôle Maladies de l'appareil digestif [CHU Toulouse]
13 CHU Grenoble
14 GRAP - Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247
15 ADEN - Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau
16 IRIB - Institute for Research and Innovation in Biomedicine
17 Service d'Hépato-Gastroentérologie [CHU Rouen]
18 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
19 Inserm U152 - Immunologie et virologie des cancers. Immunologie des interactions cellulaires et moléculaires
20 CRESS - U1153 - Equipe 2 : ECSTRA - Epidémiologie Clinique, STatistique, pour la Recherche en Santé

Background and aims: Non-O blood group promotes deep vein thrombosis and liver fibrosis in both general population and hepatitis C. We aimed to evaluate the influence of Non-O group on the outcome of Child-Pugh A cirrhotic patients.Methods: We used two prospective cohorts of Child-Pugh A cirrhosis due to either alcohol or viral hepatitis. Primary end point was the cumulated incidence of 'Decompensation' at 3 years, defined as the occurrence of ascites , hydrothorax, encephalopathy, gastrointestinal bleeding related to portal hypertension, or bilirubin >45 μmol/L. Secondary end points were the cumulated incidences of (1) 'Disease Progression' including a « decompensation» or « the occurrence of one or more parameters » among: prothrombin time (PT) <45%, albumin <28 g/L, Child-Pugh worsening (B or C vs A or B, C vs B), hepatorenal syndrome, and hepato-pulmonary syndrome, (2) other events such as non-malignant portal vein thrombosis (nmPVT), and (3) overall survival.Results: Patients (n = 1789; 59.9% Non-O group; 40.1% group O) were followed during a median of 65.4 months. At 3 years cumulated incidence of Decompensation was 8.3% in Non-O group and 7.2% in group O (P = .27). Cumulated incidence of Disease Progression was 20.7% in Non-O group and 18.9% in group O (P = .26). Cumulated incidence of nmPVT was 2.7% in Non-O group and 2.8% in group O (P = .05). At 3 years overall survival was 92.4% in Non-O group and 93.4% in group O (P = 1).Conclusion: Non-O group does not influence disease outcome in Child-Pugh A cirrhotic patients. Clinicals trial number NCT03342170.

Keywords: ABO blood group; Child-Pugh A cirrhosis; alcoholic cirrhosis; non-malignant portal vein thrombosis; outcome; viral cirrhosis

Domains: Life Sciences [q-bio]

Isabelle Ollivier-Hourmand, Yohann Repesse, Pierre Nahon, Cendrine Chaffaut, Thông Dao, et al.. ABO blood group does not influence Child‐Pugh A cirrhosis outcome: An observational study from CIRRAL and ANRS CO12 CIRVIR cohorts. Liver International, 2022, 42 (6), pp.1386-1400. ⟨10.1111/liv.15159⟩. ⟨hal-03553907⟩