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Obesity II: Establishing causal links between chemical exposures and obesity

Jerrold J Heindel 1, * Sarah Howard 1 Keren Agay-Shay 1 Juan P Arrebola 2 Karine Audouze 3 Patrick J Babin 4 Robert Barouki 3 Amita Bansal 5 Etienne Blanc 3 Matthew C Cave 6 Saurabh Chatterjee 7 Nicolas Chevalier 8 Mahua Choudhury 9 David Collier 10 Lisa Connolly 11 Xavier Coumoul 3 Gabriella Garruti 12 Michael Gilbertson 13 Lori A Hoepner 14 Alison C Holloway 15 Georges Howell 16 Christopher D Kassotis 17 Mathew K Kay Min Ji Kim 3 Dominique Lagadic-Gossmann 18, 19 Sophie Langouet 18, 19 Antoine Legrand 3 Zhuorui Li 20 Helene Le Mentec 3 Lars Lind 21 P Monica Lind 21 Robert H Lustig 22 Corinne Martin-Chouly 19, 18 Vesna Munic Kos 23 Normand Podechard 19, 18, 24 Troy A Roepke 25 Robert M Sargis 26 Anne Starling 27 Craig R Tomlinson 28 Charbel Touma 3 Jan Vondracek 29 Frederick Vom Saal 30 Bruce Blumberg 20 
Abstract : Obesity is a multifactorial disease with both genetic and environmental components. The prevailing view is that obesity results from an imbalance between energy intake and expenditure caused by overeating and insufficient exercise. We describe another environmental element that can alter the balance between energy intake and energy expenditure: obesogens. Obesogens are a subset of environmental chemicals that act as endocrine disruptors affecting metabolic endpoints. The obesogen hypothesis posits that exposure to endocrine disruptors and other chemicals can alter the development and function of the adipose tissue, liver, pancreas, gastrointestinal tract, and brain, thus changing the set point for control of metabolism. Obesogens can determine how much food is needed to maintain homeostasis and thereby increase the susceptibility to obesity. The most sensitive time for obesogen action is in utero and early childhood, in part via epigenetic programming that can be transmitted to future generations. This review explores the evidence supporting the obesogen hypothesis and highlights knowledge gaps that have prevented widespread acceptance as a contributor to the obesity pandemic. Critically, the obesogen hypothesis changes the narrative from curing obesity to preventing obesity.
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Submitted on : Friday, August 5, 2022 - 8:35:27 AM
Last modification on : Friday, August 5, 2022 - 11:57:55 AM


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Jerrold J Heindel, Sarah Howard, Keren Agay-Shay, Juan P Arrebola, Karine Audouze, et al.. Obesity II: Establishing causal links between chemical exposures and obesity. Biochemical Pharmacology, Elsevier, 2022, 199, pp.115015. ⟨10.1016/j.bcp.2022.115015⟩. ⟨hal-03705630⟩



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