Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium

Neerav Goyal (1) , Max Hennessy (1) , Erik Lehman (1) , Wenxue Lin (1) , Antonio Agudo , Wolfgang Ahrens , Stefania Boccia , Paul Brennan (2) , Hermann Brenner (3) , Gabriella Cadoni (4) , Cristina Canova , Chu Chen , David Conway (5) , Maria Paula Curado , Luigino Dal Maso , Alexander Daudt , Valeria Edefonti , Eleonora Fabianova , Leticia Fernandez , Silvia Franceschi , Werner Garavello , Maura Gillison , Richard Hayes , Claire Healy , Rolando Herrero , Ivana Holcatova , Jossy Kanda , Karl Kelsey , Bo T. Hansen , Rosalina Koifman , Pagona Lagiou , Carlo La Vecchia , Fabio Levi , Guojun Li , Jolanta Lissowska , Rossana Mendoza López , Danièle Luce (6) , Gary Macfarlane , Dana Mates , Keitaro Matsuo , Michael Mcclean , Ana Menezes , Gwenn Menvielle (7) , Hal Morgenstern , Kirsten Moysich , Eva Negri , Andrew Olshan , Tamas Pandics , Jerry Polesel , Mark Purdue , Loredana Radoi (8) , Heribert Ramroth , Lorenzo Richiardi , Stimson Schantz , Stephen Schwartz , Diego Serraino , Oxana Shangina , Elaine Smith , Erich Sturgis , Beata Świątkowska , Peter Thomson , Thomas Vaughan , Marta Vilensky , Deborah Winn , Victor Wunsch-Filho , Guo‐pei Yu , Jose Zevallos , Zuo‐feng Zhang , Tongzhang Zheng , Ariana Znaor , Paolo Boffetta (9) , Mia Hashibe (10) , Yuan‐chin Lee (10) , Joshua Muscat (1)

1 Penn State - Pennsylvania State University
2 OMS / WHO - Organisation Mondiale de la Santé / World Health Organization Office
3 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
4 IRCCS - Istituti di Ricovero e Cura a Carattere Scientifico
5 University of Glasgow
6 Irset - Institut de recherche en santé, environnement et travail
7 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
8 CESP - Centre de recherche en épidémiologie et santé des populations
9 University of Bologna/Università di Bologna
10 University of Utah School of Medicine [Salt Lake City]

Objective: We analyzed the pooled case-control data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium to compare cigarette smoking and alcohol consumption risk factors for head and neck cancer between less developed and more developed countries. Subjects and methods: The location of each study was categorized as either a less developed or more developed country. We compared the risk of overall head and neck cancer and cancer of specific anatomic subsites associated with cigarette smoking and alcohol consumption. Additionally, age and sex distribution between categories was compared. Results: The odds ratios for head and neck cancer sites associated with smoking duration differed between less developed and more developed countries. Smoking greater than 20 years conferred a higher risk for oral cavity and laryngeal cancer in more developed countries, whereas the risk was greater for oropharynx and hypopharynx cancer in less developed countries. Alcohol consumed for more than 20 years conferred a higher risk for oropharynx, hypopharynx, and larynx cancer in less developed countries. The proportion of cases that were young (<45 years) or female differed by country type for some HNC subsites. Conclusion: These findings suggest the degree of industrialization and economic development affects the relationship between smoking and alcohol with head and neck cancer.

Keywords: INHANCE; alcohol use; head and neck cancer; smoking; socioeconomic status

Domains: Life Sciences [q-bio]; Cancer

Neerav Goyal, Max Hennessy, Erik Lehman, Wenxue Lin, Antonio Agudo, et al.. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium. Oral Diseases, 2022, ⟨10.1111/odi.14196⟩. ⟨hal-03712690⟩