Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors - Université de Rennes Accéder directement au contenu
Article Dans Une Revue FEBS Letters Année : 2022

Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors

Résumé

The prevalence of metabolic diseases, such as obesity, diabetes, metabolic syndrome and chronic liver diseases among others, has been rising for several years. Epidemiology and mechanistic (in vivo, in vitro and in silico) toxicology have recently provided compelling evidence implicating the chemical environment in the pathogenesis of these diseases. In this review, we will describe the biological processes that contribute to the development of metabolic diseases targeted by metabolic disruptors, and will propose an integrated pathophysiological vision of their effects on several organs. With regard to these pathomechanisms, we will discuss the needs, and the stakes of evolving the testing and assessment of endocrine disruptors to improve the prevention and management of metabolic diseases that have become a global epidemic since the end of last century.
Fichier principal
Vignette du fichier
2020-093.pdf (461.99 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-03788441 , version 1 (21-11-2022)

Licence

Paternité

Identifiants

Citer

Kévin Bernal, Charbel Touma, Chedi Erradhouani, Talía Boronat-Belda, Lucas Gaillard, et al.. Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors. FEBS Letters, 2022, ⟨10.1002/1873-3468.14465⟩. ⟨hal-03788441⟩
71 Consultations
178 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More