Asymmetric Ruthenium Catalysis Enables Fluorophores with Point Chirality Displaying CPL Properties

Yang Sun (1) , Kais Dhbaibi (1) , Hortense Lauwick (1) , Claudia Lalli (1) , Gregory Taupier (1) , Yann Molard (1) , Rafael Gramage-Doria (1) , Sylvie Dérien (1) , Jeanne Crassous (1) , Mathieu Jérôme Achard (1)

1 ISCR - Institut des Sciences Chimiques de Rennes

A novel enantiopure π-allylruthenium(IV) precatalyst allowed the enantioselective and stereospecific allylations of indoles and gave access to indolin-3-ones containing vicinal stereogenic centers. Facile separation of diastereoisomers exhibiting opposite CPL activities in diverse solvents including water demonstrated the potential of these sustainable transformation and of the newly prepared molecules.

Keywords: chirality; enantioselectivity; stereoselectivity; fluorescence; CPL

Domains: Chemical Sciences

Yang Sun, Kais Dhbaibi, Hortense Lauwick, Claudia Lalli, Gregory Taupier, et al.. Asymmetric Ruthenium Catalysis Enables Fluorophores with Point Chirality Displaying CPL Properties. Chemistry - A European Journal, 2023, 29 (10), ⟨10.1002/chem.202203243⟩. ⟨hal-03850024⟩