Calibration of PBPK models based on in vivo and in vitro data to describe complex biotransformation processes

Dany Habka (1) , Alexandre R.R. Pery (1) , C. Aninat (2) , A. Corlu (2) , C. Guguen-Guillouzo (2) , E. Leclerc (3) , Cécile Legallais (3) , Céline Brochot (1)

1 INERIS - Institut National de l'Environnement Industriel et des Risques
2 Foie, métabolismes et cancer
3 BMBI - Biomécanique et Bioingénierie

Mots clés: PBPK; IN VITRO; IN SILICO; CALIBRATION; METABOLISME; AUTO-INDUCTION; IFOSFAMIDE

Domaines: Toxicologie; Sciences de l'environnement

Dany Habka, Alexandre R.R. Pery, C. Aninat, A. Corlu, C. Guguen-Guillouzo, et al.. Calibration of PBPK models based on in vivo and in vitro data to describe complex biotransformation processes. 12. International Congress of Toxicology (IUTOX 2010), Jul 2010, Barcelone, Spain. ⟨ineris-00970650⟩