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Article Dans Une Revue Chromosoma Année : 2010

Calpain 2 is required for sister chromatid cohesion.

Résumé

Calpains form a family of Ca(2+)-dependent cysteine proteases involved in diverse cellular processes. However, the specific functions of each calpain isoform remain unknown. Recent reports have shown that calpain 2 (Capn2) is essential for cell viability. We have recently shown that Capn2 is a nuclear protease associated with chromosomes during mitosis in mammalian embryonic cells. We now report that Capn2 depletion impairs mitosis and induces apoptosis in murine cells. Low Capn2 levels induce chromosome alignment defects, the loss of histone H3 threonine 3 phosphorylation at centromeres, and premature sister chromatid separation. Thus, Capn2 may play a role in fundamental mitotic functions, such as the maintenance of sister chromatid cohesion.

Dates et versions

inserm-00452070 , version 1 (01-02-2010)

Identifiants

Citer

Laura Magnaghi-Jaulin, Anne Marcilhac, Mireille Rossel, Christian Jaulin, Yves Benyamin, et al.. Calpain 2 is required for sister chromatid cohesion.. Chromosoma, 2010, 119 (3), pp.267-74. ⟨10.1007/s00412-010-0255-z⟩. ⟨inserm-00452070⟩
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