Embedding a cardiac pulsatile model into an integrated model of the cardiovascular regulation for heart failure followup.

Virginie Le Rolle (1) , David Ojeda (1) , Alfredo I. Hernández (1)

1 LTSI - Laboratoire Traitement du Signal et de l'Image

The analysis of followup data from patients suffering from heart failure is a difficult task, due to the complex and multifactorial nature of this pathology. In this paper, we present a coupled model, integrating a pulsatile heart into a model of the short to long-term regulations of the cardiovascular system. An interface method is proposed to couple these models, which present significantly different time scales. Results from a sensitivity analysis of the original and integrated models are proposed with simulations reproducing the main effects of the short- and long-term responses of an acute decompensated heart failure episode on a patient undergoing cardiac resynchronization therapy.

Mots clés: Cardiac resynchronization therapy; Computational modeling; heart failure

Domaines: Ingénierie biomédicale; Traitement du signal et de l'image [eess.SP]; Traitement du signal et de l'image [eess.SP]

Virginie Le Rolle, David Ojeda, Alfredo I. Hernández. Embedding a cardiac pulsatile model into an integrated model of the cardiovascular regulation for heart failure followup.. IEEE Transactions on Biomedical Engineering, 2011, 58 (10), pp.2982-6. ⟨10.1109/TBME.2011.2159715⟩. ⟨inserm-00654827⟩