Single spin-echo T2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain.

Lijing Xin (1, 2) , Giulio Gambarota (3) , Cristina Cudalbu (2) , Vladimír Mlynárik (2) , Rolf Gruetter (1, 4)

1 Departments of Radiology
2 EPFL - Ecole Polytechnique Fédérale de Lausanne
3 LTSI - Laboratoire Traitement du Signal et de l'Image
4 Departments of Radiology

OBJECT: To determine the single spin-echo T2 relaxation times of uncoupled and J-coupled metabolites in rat brain in vivo at 14.1 T and to compare these results with those previously obtained at 9.4 T. MATERIALS AND METHODS: Measurements were performed on five rats at 14.1 T using the SPECIAL sequence and TE-specific basis-sets for LCModel analysis. RESULTS AND CONCLUSION: The T2 of singlets ranged from 98 to 148 ms and T2 of J-coupled metabolites ranged from 72 ms (glutamate) to 97 ms (myo-inositol). When comparing the T2s of the metabolites measured at 14.1 T with those previously measured at 9.4 T, a decreasing trend was found (p<0.0001). We conclude that the modest shortening of T2 at 14.1 T has a negligible impact on the sensitivity of the 1H MRS when performed at TE shorter than 10 ms.

Mots clés: T2 relaxation time; coupled spin systems; brain metabolites; proton magnetic resonance localized spectroscopy

Domaines: Ingénierie biomédicale; Traitement du signal et de l'image [eess.SP]; Traitement du signal et de l'image [eess.SP]

Lijing Xin, Giulio Gambarota, Cristina Cudalbu, Vladimír Mlynárik, Rolf Gruetter. Single spin-echo T2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain.: T2 Relaxation Times of Cerebral Metabolites at 14.1 T. Magnetic Resonance Materials in Physics, Biology and Medicine, 2013, 26 (6), pp.549-54. ⟨10.1007/s10334-013-0378-3⟩. ⟨inserm-00835509⟩