A model-based approach for the evaluation of vagal and sympathetic activities in a newborn lamb.

Virginie Le Rolle (1) , David Ojeda (1) , Alain Beuchee (1, 2) , Jean-Paul Praud (3) , Patrick Pladys (1) , Alfredo I. Hernandez (1)

1 LTSI - Laboratoire Traitement du Signal et de l'Image
2 Service de Pédiatrie
3 UdeS - Département de pédiatrie [Sherbrooke]

This paper proposes a baroreflex model and a recursive identification method to estimate the time-varying vagal and sympathetic contributions to heart rate variability during autonomic maneuvers. The baroreflex model includes baroreceptors, cardiovascular control center, parasympathetic and sympathetic pathways. The gains of the global afferent sympathetic and vagal pathways are identified recursively. The method has been validated on data from newborn lambs, which have been acquired during the application of an autonomic maneuver, without medication and under beta-blockers. Results show a close match between experimental and simulated signals under both conditions. The vagal and sympathetic contributions have been simulated and, as expected, it is possible to observe different baroreflex responses under beta-blockers compared to baseline conditions.

Domaines: Ingénierie biomédicale; Traitement du signal et de l'image [eess.SP]; Traitement du signal et de l'image [eess.SP]

Virginie Le Rolle, David Ojeda, Alain Beuchee, Jean-Paul Praud, Patrick Pladys, et al.. A model-based approach for the evaluation of vagal and sympathetic activities in a newborn lamb.. Conference proceedings : .. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2013, 2013, pp.3881-4. ⟨10.1109/EMBC.2013.6610392⟩. ⟨inserm-00881084⟩