Wnt-regulated dynamics of positional information in zebrafish somitogenesis
Résumé
How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of cellular change in a flow of cells during somitogenesis. Using time-controlled perturbations of Wnt signaling in the zebrafish embryo, we changed segment length without altering the rate of somite formation or embryonic elongation. This result implies specific Wnt regulation of the wavefront velocity. The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information.
Mots clés
Animals
Genetically Modified
Basic Helix-Loop-Helix Transcription Factors
Body Patterning
Fibroblast Growth Factors
Gene Expression Regulation
Developmental
Heat-Shock Response
Intercellular Signaling Peptides and Proteins
T-Box Domain Proteins
Wnt Proteins
Wnt Signaling Pathway
Zebrafish
Zebrafish Proteins
Somites
Biological
Models
Domaines
Génétique
Fichier principal
Wnt-regulated dynamics of positional-version of record-CCBY.pdf (5.43 Mo)
Télécharger le fichier
Origine : Publication financée par une institution
Loading...