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Le trouble obsessionnel-compulsif, un nouveau modèle de dysfonction des noyaux gris centraux ? Apports de la stimulation cérébrale profonde [Obsessive-compulsive disorder, a new model of basal ganglia dysfunction? Elements from deep brain stimulation studies].

Abstract : Deep brain stimulation was first developed for movement disorders but is now being offered as a therapeutic alternative in severe psychiatric disorders after the failure of conventional therapies. One of such pathologies is obsessive-compulsive disorder. This disorder which associates intrusive thoughts (obsessions) and repetitive irrepressible rituals (compulsions) is characterized by a dysfunction of a cortico-subcortical loop. After having reviewed the pathophysiological evidence to show why deep brain stimulation was an interesting path to take for severe and resistant cases of obsessive-compulsive disorder, we will present the results of the different clinical trials. Finally, we will provide possible mechanisms for the effects of deep brain stimulation in this pathology.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01133879
Contributor : Laurent Jonchère <>
Submitted on : Friday, March 20, 2015 - 3:30:33 PM
Last modification on : Wednesday, June 6, 2018 - 10:00:04 AM

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W I A Haynes, B Millet, L Mallet. Le trouble obsessionnel-compulsif, un nouveau modèle de dysfonction des noyaux gris centraux ? Apports de la stimulation cérébrale profonde [Obsessive-compulsive disorder, a new model of basal ganglia dysfunction? Elements from deep brain stimulation studies].. Revue Neurologique, Elsevier Masson, 2012, 168 (8-9), pp.649-54. ⟨10.1016/j.neurol.2012.05.004⟩. ⟨hal-01133879⟩

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