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Interleukin 6 inhibits HBV entry through NTCP down regulation.

Abstract : Hepatitis B virus (HBV) infection is a major public health problem. Recently, the human liver bile acid transporter Na+/taurocholate cotransporting polypeptide (NTCP) has been identified as an HBV specific receptor. NTCP expression is known to be strongly regulated by IL-6. This study was aimed at characterizing the effect of IL-6 on HBV entry. HBV entry was inhibited by up to 90% when cells were pretreated with IL-6 as shown by a strong inhibition of long term HBsAg secretion. This effect was confirmed by showing a severe reduction of intracellular HBV cccDNA. In parallel, we observed a 98% decrease in NTCP mRNA steady state level and an 80% reduction in NTCP-mediated taurocholate uptake. IL-6-mediated inhibition of NTCP-mediated taurocholate uptake and viral entry exhibited similar dose-dependence and kinetics while restoration of NTCP expression suppressed the inhibitory effect of IL-6. NTCP-mediated HBV entry is therefore markedly inhibited by IL-6.
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Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Monday, March 23, 2015 - 10:19:51 AM
Last modification on : Wednesday, March 30, 2022 - 2:35:53 PM

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Fidaa Bouezzedine, Olivier Fardel, Philippe Gripon. Interleukin 6 inhibits HBV entry through NTCP down regulation.. Virology, Elsevier, 2015, 481, pp.34-42. ⟨10.1016/j.virol.2015.02.026⟩. ⟨hal-01134184⟩



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