Fine and Clean Photothermally Controlled NIR Drug Delivery from Biocompatible Nickel-bis(dithiolene)-Containing Liposomes

Kenny Mebrouk 1 Mathieu Ciancone 1 Thomas Vives 1 Sandrine Cammas-Marion 1 Thierry Benvegnu 1 Catherine Le Goff-Gaillard 2 Yannick Arlot-Bonnemains 2 Marc Fourmigué 1 Franck Camerel 1, *
* Auteur correspondant
1 ISCR - Institut des Sciences Chimiques de Rennes
2 IGDR - Institut de Génétique et Développement de Rennes
Abstract : This work demonstrates that metal-bis(dithiolene) complexes can be efficiently incorporated inside organic nanocarriers and, that under near-infrared (NIR) irradiation, their high photothermal activity can be finely used to release encapsulated drugs on demand. In contrast to gold nanoparticles and other organic NIR dyes, nickel-bis(dithiolene) complexes do not produce singlet oxygen under irradiation, a highly desirable characteristic to preserve the chemical integrity and activity of the loaded drug during the NIR-triggered release from the nanocarriers. Finally, cytotoxicity experiments performed on various cell lines have shown that the incorporation of such metal complexes do not increase the toxicity of the final liposomal formulation. These results offer great promise for the development of innovative biocompatible drug nanocargos that are able to safely deliver their content on demand under NIR laser irradiation. Moreover, this work demonstrates that metal-bis(dithiolene) complexes, owing to their versatility of functionalization and metal complexation, are attractive photothermal agents for the development of original NIR-responsive materials for application not only in biotechnology but also in materials science.
Keywords : drug delivery Liposomes nickel-bis(dithiolene) photothermal Liposome Nickel-bis(dithiolene) Photothermal Drug delivery Controlled release
Type de document :
Article dans une revue
ChemMedChem, Wiley-VCH Verlag, 2017, 12, pp.1753-1758. 〈10.1002/cmdc.201700344〉
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Soumis le : lundi 4 décembre 2017 - 13:44:09
Dernière modification le : lundi 11 février 2019 - 11:36:36

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Kenny Mebrouk, Mathieu Ciancone, Thomas Vives, Sandrine Cammas-Marion, Thierry Benvegnu, et al.. Fine and Clean Photothermally Controlled NIR Drug Delivery from Biocompatible Nickel-bis(dithiolene)-Containing Liposomes. ChemMedChem, Wiley-VCH Verlag, 2017, 12, pp.1753-1758. 〈10.1002/cmdc.201700344〉. 〈hal-01640113〉

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