Diffuse T1-MRI White Matter Volume Decrease in Patients with Sickle Cell Disease

Soyoung Choi (1) , Adam Bush (1) , Matt Borzage , Anand Joshi (2) , Vidya Rajagopalan (1) , Julie Coloigner (3, 1) , Natasha Lepore (1) , Thomas D. Coates (1) , John Wood (1)

1 Children’s Hospital Los Angeles [Los Angeles]
2 USC - University of Southern California
3 LTSI - Laboratoire Traitement du Signal et de l'Image

Sickle cell disease (SCD) is a genetic blood disorder associated with anemia, chronic vascular damage, overt stroke, silent cerebral infarctions, and early mortality. Patients with SCD have increased cerebral blood flow to compensate for their anemia but nevertheless exhibit regional cerebralhypo-perfusion and neurocognitive decline. Previous volumetric studies in SCD have shown delayed growth, gray matter (GM) loss, white matter (WM) loss, and decreased cortical thickness compared with control subjects. Diffusion-tensor imaging have demonstrated compromised WM integrity in major fiber pathways diffusely throughout the brain. Further regional investigations of structural outcome could potentially help expand our understanding of the neurobiology of SCD

Domains: Image Processing [eess.IV]; Imaging; Neurons and Cognition [q-bio.NC]

Soyoung Choi, Adam Bush, Matt Borzage, Anand Joshi, Vidya Rajagopalan, et al.. Diffuse T1-MRI White Matter Volume Decrease in Patients with Sickle Cell Disease. 21sy Annual meeting of the Organization for Human Brain Mapping, Apr 2015, Honolulu, HI, United States. . ⟨hal-01792279⟩