Stereoretentive Olefin Metathesis Made Easy: In Situ Generation of Highly Selective Ruthenium Catalysts from Commercial Starting Materials

Daniel S Müller (1) , Idriss Curbet (1) , Yann Raoul , Jérôme Le Nôtre , Olivier Baslé (1) , Marc Mauduit (1)

1 ISCR - Institut des Sciences Chimiques de Rennes

The in situ preparation of highly stereoretentive ruthenium-based metathesis catalysts is reported. This approach completely avoids the isolation of intermediates and air-sensitive catalysts, thus allowing for the rapid access and evaluation of numerous dithiolate Ru catalysts. A procedure was established to perform cross-metathesis reactions without the use of a glovebox, and on a small scale even Schlenk techniques are not required. Consequently, the chemistry displayed in this report is available to every practicing organic chemist and presents a powerful approach for the identification of new stereoretentive catalysts.

Domaines: Chimie

Daniel S Müller, Idriss Curbet, Yann Raoul, Jérôme Le Nôtre, Olivier Baslé, et al.. Stereoretentive Olefin Metathesis Made Easy: In Situ Generation of Highly Selective Ruthenium Catalysts from Commercial Starting Materials. Organic Letters, 2018, 20 (21), pp.6822-6826. ⟨10.1021/acs.orglett.8b02943⟩. ⟨hal-01903312⟩