Spectroscopic and single-crystal X-ray diffraction studies of enantiomeric copper(II) Schiff base one-dimensional coordination polymers with 4-(2-aminoethyl)benzenesulfonamide appendage Comprehensive biological evaluation (DNA binding, cleavage, superoxide dismutase mimetic activity, topoisomerase I inhibition and cytotoxicity)

Abstract : New chiral Cu(II)-based one-dimensional coordination polymers [l-C 25 H 27 CuN 3 O 6 S] (1a) and [d-C 25 H 27 CuN 3 O 6 S] (1b) were designed and synthesized by in situ reaction of Schiff base (o-vanillin and l-/d-phenylalanine) and appended ligand 4-(2-aminoethyl)benzenesulfonamide incorporated with Cu(II) ion. The enantiomeric complexes 1a and 1b were fully characterized using various spectroscopic techniques and single-crystal X-ray diffraction studies. The enantiomeric analogues 1a and 1b crystallized in chiral monoclinic P21 space group with z = 2 exhibiting a distorted square pyramidal environment around Cu(II) metal centre coordinated to N 2 O 3 donor atoms with apical position occupied by adjacent bridging carboxylate oxygen, resulting in one-dimensional polymeric chain structures. Comprehensive biological studies of 1a and 1b (DNA binding, superoxide dismutase (SOD), topoisomerase I and cytotoxic activity) were performed which revealed that 1a showed better prospects as a therapeutic drug candidate as compared to 1b as quantified by their comparative DNA binding (K b , K and K sv values), SOD mimetic activity (IC 50 values of 0.160 and 0.198, respectively) and anticancer properties. © 2019 John Wiley and Sons, Ltd.
Document type :
Journal articles
Complete list of metadatas

https://hal-univ-rennes1.archives-ouvertes.fr/hal-02161852
Contributor : Laurent Jonchère <>
Submitted on : Friday, June 21, 2019 - 10:47:24 AM
Last modification on : Wednesday, June 26, 2019 - 11:51:58 AM

Identifiers

Citation

Z. Afsan, T. Roisnel, S. Tabassum, F. Arjmand. Spectroscopic and single-crystal X-ray diffraction studies of enantiomeric copper(II) Schiff base one-dimensional coordination polymers with 4-(2-aminoethyl)benzenesulfonamide appendage Comprehensive biological evaluation (DNA binding, cleavage, superoxide dismutase mimetic activity, topoisomerase I inhibition and cytotoxicity). Applied Organometallic Chemistry, Wiley-Blackwell, 2019, 33 (7), pp.e4958. ⟨10.1002/aoc.4958⟩. ⟨hal-02161852⟩

Share

Metrics

Record views

11