Skip to Main content Skip to Navigation
Journal articles

Gold(iii) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents

Abstract : The anticancer, antimicrobial and antiplasmodial activities of six gold(iii) bis(dithiolene) complexes were studied. Complexes 1-6 showed relevant anticancer properties against A2780/A2780cisR ovarian cancer cells (IC50 values of 0.08-2 μM), also being able to overcome cisplatin resistance in A2780cisR cells. Complex 1 also exhibited significant antimicrobial activity against Staphylococcus aureus (minimum inhibitory concentration (MIC) values of 12.1 ± 3.9 μg mL-1) and both Candida glabrata and Candida albicans (MICs of 9.7 ± 2.7 and 19.9 ± 2.4 μg mL-1, respectively). In addition, all complexes displayed antiplasmodial activity against the Plasmodium berghei parasite liver stages, even exhibiting better results than the ones obtained using primaquine, an anti-malarial drug. Mechanistic studies support the idea that thioredoxin reductase, but not DNA, is a possible target of these complexes. Complex 1 is stable under biological conditions, which would be important if this compound is ever to be considered as a drug. Overall, the results obtained evidenced the promising biological activity of complex 1, which might have potential as a novel anticancer, antimicrobial and antiplasmodial agent to be used as an alternative to current therapeutics.
Document type :
Journal articles
Complete list of metadatas

Cited literature [107 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-02635131
Contributor : Laurent Jonchère <>
Submitted on : Thursday, June 18, 2020 - 11:17:41 AM
Last modification on : Wednesday, August 26, 2020 - 2:18:25 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2020-10-27

Please log in to resquest access to the document

Identifiers

Citation

Diana Fontinha, Sílvia A Sousa, Tânia S Morais, Miguel Prudêncio, Jorge H Leitão, et al.. Gold(iii) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents. Metallomics, Royal Society of Chemistry, 2020, 12 (6), pp.974-987. ⟨10.1039/d0mt00064g⟩. ⟨hal-02635131⟩

Share

Metrics

Record views

18