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Journal Articles Journal of Clinical Medicine Year : 2022

Presentation and Prognosis of Primary Expansile and Infiltrative Mucinous Carcinomas of the Ovary

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Cyril Touboul
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  • PersonId : 1093043
Yohann Dabi
  • Function : Author
  • PersonId : 1085062
Yohan Kerbage
  • Function : Author
  • PersonId : 1150279
  • IdRef : 200078461
Lise Lecointre
  • Function : Author
  • PersonId : 1077590
Alexandre Bricou
  • Function : Author
  • PersonId : 1085065
Geoffroy Canlorbe
  • Function : Author
  • PersonId : 963071
Sofiane Bendifallah
  • Function : Author
  • PersonId : 1077592
Tristan Gauthier
  • Function : Author
  • PersonId : 1033835

Abstract

Objective: The aim of the present study was to evaluate evolution and prognosis of mucinous ovarian carcinomas (mOC), with respect to the two invasive patterns: expansile and infiltrative invasion. Methods: This was a descriptive, retrospective, multicenter study conducted in 13 French centres from 1 January 2001 to 31 December 2019. All patients operated on for epithelial ovarian neoplasia of the mucinous type (infiltrative/ expansile) were included, whether the surgery was performed immediately or after neoadjuvant chemotherapy. Results: A total of 94 women with mucinous carcinomas were included in the present study. Mucinous tumours were divided into 35 expansile (37%) and 59 infiltrative (63%) mOC. There was a statistically significant difference in early and late stages at initial diagnosis between expansile and infiltrative mOC. None of the expansile mOC showed metastatic lymph nodes, whereas almost a quarter of the infiltrative mOC were metastatic to the pelvic /para-aortic region. There was a clear difference in RFS, in favour of expansile mOC, with 90% survival at 5 years, compared with 60% for infiltrative mOC. Conclusions: Although infiltrative and expansile mOC belong to the same histological family, they present many distinctions in clinical presentation, histological invasion, and disease course.
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hal-03886170 , version 1 (06-12-2022)

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Attribution - CC BY 4.0

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Marine Huin, Jerome Lorenzini, Flavie Arbion, Xavier Carcopino, Cyril Touboul, et al.. Presentation and Prognosis of Primary Expansile and Infiltrative Mucinous Carcinomas of the Ovary. Journal of Clinical Medicine, 2022, 11 (20), pp.6120. ⟨10.3390/jcm11206120⟩. ⟨hal-03886170⟩
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