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Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study

David Luque-Paz 1, 2, * Pierre Tattevin 1, 2, 3 Paul Loubet 4, 5, 6 François Bénézit 1 Vincent Thibault 1 Fabrice Lainé 3, 1, 6 Philippe Vanhems 7, 8 Selilah Amour 7 Bruno Lina 7 Xavier Duval 6, 9 Anne-Sophie L’honneur 10 Nadhira Fidouh 11 Christine Vallejo 12 Sophie Alain 13 Florence Galtier 14 Vincent Foulongne 15 Gisèle Lagathu 1 Nezha Lenzi 6 Zineb Lesieur 6 Odile Launay 16 Stéphane Jouneau 1, 17 P. Loulergue S. Momcilovic J. Mira N. Marin J. Charpentier A. Regent R. Kanaan F. Dumas B. Doumenc M. Lachatre T. Szwebel J. Kansao y. Costa J. Alexandra H. Becheur K. Belghalem J. Bernard A. Bleibtreu M. Boisseau R. Bories O. Brugiere F. Brunet C. Burdet E. Casalino M. Caseris C. Chansiaux M. Chauchard P. Chavance C. Choquet A. Cloppet-Fontaine L. Colosi B. Couset B. Crestani F. Crocket A. Debit K Delanoe V. Descamps P. Dieude A. Dossier N. Douron E. Dupeyrat N. Emeyrat C. Fernet T. Goulenok S. Harent R. Jouenne A. Justet A. Leleu I. Lerat M. Lilamand H. Mal A. Marceau A.-C. Metivier K. Oplelatora T. Papo A.-L. Pelletier L. Pereira P. Pradere R Prommier P. Ralainnazava M. Ranaivoision A. Raynaud-Simon C. Rioux K. Sacre V. Verry V. Vuong y. yazdapanah N. Houhou P. Géraud V. Driss V. Maugueret L. Crantelle C. Agostini M. Ray F. Letois T. Mura C. Serrand S. Noslier A. Giordano H. Chevassus E. Nyiramigisha C. Merle A. Bourdin 18, 19 A. Konaté X. Capdevilla G. Du Cailar A. Terminet H. Blain M. Leglise A. Le Quellec P. Corne L. Landreau K. Klouche 18, 19 A. Bourgeois M. Sebbane G. Mourad H. Leray D. Postil S. Alcolea E. Couve-Deacon S. Rogez L. Argaud M. Cour R. Hernu M. Simon T. Baudry K. Tazarourte C. Bui-Xuan J. Fattoum M. Valette S. Rochas S. Cochennec E. Thébault M. Revest M. Sébillotte A. Le Bot M. Baldeyrou S. Patrat-Delon M. Cailleaux C. Pronier 
Abstract : Inhaled corticosteroids (ICS) have been associated with increased risk of pneumonia. Their impact on respiratory virus infections is unclear. We performed a post-hoc analysis of the FLUVAC cohort, a multicenter prospective cohort study of adults hospitalized with influenza-like illness (ILI) during six consecutive influenza seasons (2012–2018). All patients were tested for respiratory virus infection by multiplex PCR on nasopharyngeal swabs and/or bronchoalveolar lavage. Risk factors were identified by logistic regression analysis. Among the 2658 patients included, 537 (20.2%) were treated with ICS before admission, of whom 282 (52.5%, 282/537) tested positive for at least one respiratory virus. Patients on ICS were more likely to test positive for non-influenza respiratory viruses (25.1% vs. 19.5%, P = 0.004), especially for adenovirus (aOR 2.36, 95% CI 1.18–4.58), and respiratory syncytial virus (aOR 2.08, 95% CI 1.39–3.09). Complications were reported in 55.9% of patients on ICS (300/537), primarily pneumonia (171/535, 32%). Among patients on chronic ICS who tested positive for respiratory virus, 14.2% (40/282) were admitted to intensive care unit, and in-hospital mortality rate was 2.8% (8/282). Chronic use of ICS is associated with an increased risk of adenovirus or RSV infections in patients admitted for ILI.
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Submitted on : Monday, March 14, 2022 - 2:56:50 PM
Last modification on : Thursday, May 19, 2022 - 4:18:02 PM
Long-term archiving on: : Wednesday, June 15, 2022 - 6:42:53 PM

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David Luque-Paz, Pierre Tattevin, Paul Loubet, François Bénézit, Vincent Thibault, et al.. Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study. Scientific Reports, Nature Publishing Group, 2022, 12 (1), pp.4199. ⟨10.1038/s41598-022-08089-0⟩. ⟨hal-03607627⟩

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