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Journal Articles RSC Advances Year : 2016

Functionalization of pyridyl ketones using deprotolithiation-in situ zincation

Abstract

The metallation of aryl ketones was achieved by using LiTMP in the presence of ZnCl2 center dot TMEDA, as evidenced by subsequent interception with iodine or by a palladium-catalysed cross-coupling reaction. One of the synthesized iodo ketones has been further elaborated to reach derivatives of biological interest.
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Dates and versions

hal-01357392 , version 1 (28-06-2022)

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Madani Hedidi, William Erb, Frédéric Lassagne, Yury S. Halauko, Oleg A. Ivashkevich, et al.. Functionalization of pyridyl ketones using deprotolithiation-in situ zincation. RSC Advances, 2016, 6 (68), pp.63185--63189. ⟨10.1039/c6ra11370b⟩. ⟨hal-01357392⟩
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