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Functionalization of pyridyl ketones using deprotolithiation-in situ zincation

Abstract : The metallation of aryl ketones was achieved by using LiTMP in the presence of ZnCl2 center dot TMEDA, as evidenced by subsequent interception with iodine or by a palladium-catalysed cross-coupling reaction. One of the synthesized iodo ketones has been further elaborated to reach derivatives of biological interest.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01357392
Contributor : Laurent Jonchère <>
Submitted on : Monday, August 29, 2016 - 4:40:43 PM
Last modification on : Thursday, March 5, 2020 - 2:03:16 PM

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Madani Hedidi, William Erb, Frédéric Lassagne, Yury S. Halauko, Oleg A. Ivashkevich, et al.. Functionalization of pyridyl ketones using deprotolithiation-in situ zincation. RSC Advances, Royal Society of Chemistry, 2016, 6 (68), pp.63185--63189. ⟨10.1039/c6ra11370b⟩. ⟨hal-01357392⟩

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